Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 9

Design and Development of Novel Floating In Situ Gel of Amoxicillin for the Treatment of Peptic Ulcer Disease Caused by Helicobacter pylori

Mukesh S Patel1*, Alpesh D Patel1, Nidhi R Doshi2 and Govind Vyas3

1Department of Pharmaceutics, Shri B.M. Shah College of Pharmaceutical Education and Research, Gujarat, India
2Research Scholar, Gujarat Technological University, Ahmedabad, Gujarat, India
3Director, Research and Development, Invahealth. Inc Cranberry, NJ, USA

*Corresponding Author: Mukesh S Patel, Department of Pharmaceutics, Shri B.M. Shah College of Pharmaceutical Education and Research, Gujarat, India.

Received: August 02, 2021; Published: August 28, 2021

Abstract

  The purpose of this work was to prepare a novel intragastric flotation system for controlled administration of amoxicillin for the treatment of peptic ulcers. By preparing controlled release floating in situ of amoxicillin reduce dosing frequency, better patient compliance, improve bioavailability of drug and minimize side effects. Large doses of amoxicillin (750 -1000 mg) can be easily provided in liquid dosage form, which is difficult to integrate into floating tablets. Natural Polymer-based floating gelation system was prepared by dissolving different concentrations of xanthan gum and guar gum in deionized water, then drug (Amoxicillin) and calcium carbonate were added. Fourier transform infrared spectroscopy was used to confirm the presence of interactions between drugs and excipients. 32 experimental designs were used for optimization of formulation. The amount of gellan gum (X1) and calcium chloride (X2) were chosen as independent variables. The amount of drug released after 3 hours (Q3) and 6 hours (Q6) and 9 hours (Q9), the viscosity and the floating delay time of the liquid formulation were selected as dependent variables. Floating In-situ gels have been studied for their viscosity, in vitro buoyancy and drug release. The optimized formulation F6 provided sustained in vitro release of drug over an extended period of time up to 12 hrs. The drug release from gel structure follows a zero order release. As per the result and discussion the batch F6 is optimized batch which contain drug release 95.78% up to 12 hr, 67.12% swelling index and show the maximum similarity factor 65.09. FIIR studies showed that there were no interaction between drug and polymer. The stability studies revealed that there were no significant changes in the dependable parameters of the formulation. It is clearly indicates that the optimize formulation were stable for 3 months. In nutshell, we can conclude that the formulated floating in situ gel were successfully formulated for the treatment of the of Peptic Ulcer Disease Caused By Helicobacter pylori.

Keywords: In Situ Gel; Amoxicillin; Floating Drug Delivery; Gastric Residence Time; Controlled Delivery

References

  1. Adebisi A., et al. “Gastro retentive microparticles for drug delivery applications”. Journal of Microencapsulation 28 (2011): 689-708.
  2. Bhardwaj L., et al. “A Short Review on Gastro Retentive Formulations for Stomach Specific Drug Delivery”. African Journal of Basic and Applied Sciences 3 (2011): 300-312.
  3. Nayak A, et al. “Gastroretentive drug delivery systems: a review”. Asian Journal of Pharmaceutical and Clinical Research 3 (2010): 1-10.
  4. Timmermans A., et al. “How well floating dosage do forms float?” International Journal of Pharmaceutics 62 (1990): 207-216.
  5. Desai SA., et al. “Novel floating controlled release drug delivery system based on a dried gel matrix network”. Jamaica, NY; St John’s University (1984): 151-163.
  6. Vantrappen GR., et al. “The secretory component of interdigestive migratory motor complex in man”. Scand Journal of Gastroenterology 14 (1979): 663-667.
  7. Doshi N., et al. “In Situ Gel. A novel approach of gastro retentive drug delivery”. Asian Journal of Pharmaceutical Sciences 3 (2013): 1-14.
  8. Patel MS., et al. “Design and development of gastro retentive floating tablet of fluvastatin sodium”. International Journal of Universal Pharmacy and Bio Sciences 3 (2014): 391-421.
  9. Shukla S., et al. “A Review On: Recent Advancement of Stomach Specific Floating Drug Delivery”. International Journal of Pharmaceutical and Biological Archives 2 (2011): 1561-1568.
  10. Sunil K., et al. “Gastro Retentive Drug Delivery System: Features and Facts”. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (2012): 125-130.
  11. Talukder R., et al. “Gastroretentive Delivery Systems: A Mini Review”. Drug Development and Industrial Pharmacy 30 (2004): 1019-1028.
  12. Whitehead L., et al. “Development of a Gastroretentive dosage form”. European Journal of Pharmaceutical Sciences 4 (1996): 182-190.
  13. Patel N., et al. “Floating drug delivery system: An innovative acceptable approach in Gastro retentive drug delivery”. Asian Journal of Pharmaceutical Research 2 (2012): 7-18.
  14. Shep Santosh et al. “Swelling system: A novel approach towards Gastroretentive drug delivery system”. Indo-Global Journal of Pharmaceutical Sciences 1 (2011): 234-242.
  15. Patel MS., et al. “Application of Quality by Design (QbD) to Develop Dual Release Reconstitutable Oral Suspension (DRROS) of Cefpodoxime Proxetil (CPDP) for Pediatric Patients for the Treatment of Respiratory Tract and Urinary Tract Infections”. Journal of Pharmaceutical Innovation (2021).
  16. Jivani R., et al. “Development of a Novel Floating In-situ Gelling System for Stomach Specific Drug Delivery of the Narrow Absorption Window Drug Baclofen”. Iranian Journal of Pharmaceutical Research 9 (2010): 359-368.
  17. Shailaja P., et al. “Formulation and evaluation of floating in situ gel of ciprofloxacin”. International Journal of Applied Pharmaceutics 11 (2019): 1998.
  18. Kranthi Kumar K., et al. “Formulation and evaluation of floating in situ gelling system of losartan potassium”. Der Pharmacia Lettre 7 (2015): 98-112.
  19. Srilatha KS., et al. “Design of Floating In Situ Gel Of Mucolytic Agent By Cation Induced Gelation Of Natural Polysaccharides”. World Journal of Pharmacy and Pharmaceutical Sciences 6 (2017): 2104-2116.
  20. Swetha S., et al. “A comprehensive Review on Gastroretentive Drug Delivery Systems”. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (2012): 1285-1293.
  21. Gaikwad V., et al “Formulation and evaluation of in situ gel of metoprolol tartrate for nasal delivery”. Journal of Pharmacy Research 3 (2010): 788-793.
  22. Majithiya R J., et al. “Thermo reversible mucoadhesive gel for Nasal delivery of Sumatriptan”. AAPS Pharma Sci Tech 7 (2006): 1-7.
  23. Nandgude T., et al. “Formulation and Evaluation of pH induced in situ nasal gel of salbutamol Sulphate”. International Journal of Pharmaceutical Sciences and Nanotechnology 1 (2008): 177-182.
  24. Supriya S., et al. “Sustain release floating drug delivery system of in situ gelling suspension of Cinnarizine”. Journal of Pharmacy Research 1 (2011): 53-64.
  25. Prannoy T., et al. “Design and Optimization of Hydrodynamically balanced oral In-situ gel of Lamotrigine”. Research Journal of Pharmacy and Technology 13 (2020): 4865-4870.
  26. Antony JE., et al. “Formulation and evaluation of stomach specific floating in situ gel of Clarithromycin”. International Journal of Pharmaceutical Sciences and Research 11 (2020): 1479-1487.
  27. Esmaeil AH., et al. “Development and Characterization of In Situ Gel Containing Leflunomide as a Gastro-retentive Drug Delivery”. International Journal of Pharmaceutical Sciences Review and Research 64 (2020): 8-16.

Citation

Citation: Mukesh S Patel., et al. “Design and Development of Novel Floating In Situ Gel of Amoxicillin for the Treatment of Peptic Ulcer Disease Caused by Helicobacter pylori". Acta Scientific Pharmaceutical Sciences 5.9 (2021): 81-93.

Copyright

Copyright: © 2021 Mukesh S Patel., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 15, 2022.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US