Design and Development of Novel Floating In Situ Gel of Amoxicillin for the Treatment of Peptic Ulcer Disease Caused by Helicobacter pylori
Mukesh S Patel1*, Alpesh D Patel1, Nidhi R Doshi2 and Govind Vyas3
1Department of Pharmaceutics, Shri B.M. Shah College of Pharmaceutical Education and Research, Gujarat, India
2Research Scholar, Gujarat Technological University, Ahmedabad, Gujarat, India
3Director, Research and Development, Invahealth. Inc Cranberry, NJ, USA
*Corresponding Author: Mukesh S Patel, Department of Pharmaceutics, Shri B.M. Shah College of Pharmaceutical Education and Research, Gujarat, India.
August 02, 2021; Published: August 28, 2021
The purpose of this work was to prepare a novel intragastric flotation system for controlled administration of amoxicillin for the treatment of peptic ulcers. By preparing controlled release floating in situ of amoxicillin reduce dosing frequency, better patient compliance, improve bioavailability of drug and minimize side effects. Large doses of amoxicillin (750 -1000 mg) can be easily provided in liquid dosage form, which is difficult to integrate into floating tablets. Natural Polymer-based floating gelation system was prepared by dissolving different concentrations of xanthan gum and guar gum in deionized water, then drug (Amoxicillin) and calcium carbonate were added. Fourier transform infrared spectroscopy was used to confirm the presence of interactions between drugs and excipients. 32 experimental designs were used for optimization of formulation. The amount of gellan gum (X1) and calcium chloride (X2) were chosen as independent variables. The amount of drug released after 3 hours (Q3) and 6 hours (Q6) and 9 hours (Q9), the viscosity and the floating delay time of the liquid formulation were selected as dependent variables. Floating In-situ gels have been studied for their viscosity, in vitro buoyancy and drug release. The optimized formulation F6 provided sustained in vitro release of drug over an extended period of time up to 12 hrs. The drug release from gel structure follows a zero order release. As per the result and discussion the batch F6 is optimized batch which contain drug release 95.78% up to 12 hr, 67.12% swelling index and show the maximum similarity factor 65.09. FIIR studies showed that there were no interaction between drug and polymer. The stability studies revealed that there were no significant changes in the dependable parameters of the formulation. It is clearly indicates that the optimize formulation were stable for 3 months. In nutshell, we can conclude that the formulated floating in situ gel were successfully formulated for the treatment of the of Peptic Ulcer Disease Caused By Helicobacter pylori.
Keywords: In Situ Gel; Amoxicillin; Floating Drug Delivery; Gastric Residence Time; Controlled Delivery
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