Mohd Ayyub¹*, Mohammad Mukim^3,4, Mohsina F Patwekar², Faheem I Patwekar², Pratishtha Sharma⁵, Rajiv Kukkar⁵, Rakesh Patel⁴ and Tarique Mahmood¹

¹Faculty of Pharmacy, Integral University, Lucknow, UP, India
²Luqman College of Pharmacy, Gulbarga, India
³Kota College of Pharmacy, Kota, Rajasthan, India
⁴Dr. A.P.J Abdul Kalam University, Indore, MP, India
⁵School of Pharmacy, Raffles University, Alwar, Rajasthan, India

*Corresponding Author: Mohd Ayyub, Faculty of Pharmacy, Integral University, Lucknow, UP, India.

Received: January 27, 2021; Published: August 28, 2021

Abstract

Centella asiatica is a well-established plant in both of the traditional system of medicine in Ayurveda and Unani. In Ayurveda, the plant is reported in the treatment of hyperglycemia and as a blood purifier. The plant is having in vitro antioxidant and free radical scavenging activity, hypoglycemic activity, and cardioprotective effect. Centella asiatica is the chief ingredient in many of the polyherbal formulations used in ayurveda and unani viz. Abana. Centella asiatica has been proved as a good hypoglycemic. The present study was conducted on a 14 day model in which the effect of Centella asiatica extract was observed on STZ induced diabetic rats that were fed with high fat diet (HFD). Diabetes induced by STZ (50 mg/kg) i.p. injection. All the animals were allocated into 7 different groups following two types of dietary regimen. Normal pellet diet (NPD) and high fat diet (HFD) to observe the effects of STZ in presence of each groups except NC. Daily food and water was measured. Hyperlipidemia induced by feeding with HFD to all animal except NC. The parameters for evaluation of antihyperlipidemic and antihyperglycemic activities are the physical parameters and the biochemical estimation. These are blood glucose level, food efficiency ratio, liver weight, heart weight, lipid profile, biochemical marker and histopathological studies of aorta. The diabetic hyperlipidemic group showed marked elevation and the pre-treatment groups showed significant decrease in theses parameters as compared to D-HFD group (p < 0.01). In biochemical estimations various enzymes like Total cholesterol (TC), Triglyceride (TG). The diabetic hyperlipidemic group shows marked elevation and the pre-treatment groups show significant control in theses parameters as compared to D-HFD group (p < 0.01). The result of this study showed that alcoholic extract Centella asiatica (500 mg/kg) has significant antidiabetic and anti hyperlipidemic activity against streptozocin and high fat diet induced diabetic hyperlipidemic rats. All these results were compared and found to be similar with two standard drugs metformin (500 mg/kg) and atorvastatin (10 mg/Kg).

Keywords: Hyperlipidemia; Centella asiatica; Ayurveda

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Citation

Citation: Mohd Ayyub., et al. “Effect of Ethanolic Extract of Centella asiatica against Streptozocin and High Fat Diet Induced Diabetes and Hyperlipidemia in Rats". Acta Scientific Pharmaceutical Sciences 5.9 (2020): 70-80.

Copyright

Copyright: © 2020 Mohd Ayyub., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.