Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 9

Effect of Ethanolic Extract of Centella asiatica against Streptozocin and High Fat Diet Induced Diabetes and Hyperlipidemia in Rats

Mohd Ayyub1*, Mohammad Mukim3,4, Mohsina F Patwekar2, Faheem I Patwekar2, Pratishtha Sharma5, Rajiv Kukkar5, Rakesh Patel4 and Tarique Mahmood1

1Faculty of Pharmacy, Integral University, Lucknow, UP, India
2Luqman College of Pharmacy, Gulbarga, India
3Kota College of Pharmacy, Kota, Rajasthan, India
4Dr. A.P.J Abdul Kalam University, Indore, MP, India
5School of Pharmacy, Raffles University, Alwar, Rajasthan, India

*Corresponding Author: Mohd Ayyub, Faculty of Pharmacy, Integral University, Lucknow, UP, India.

Received: January 27, 2021; Published: August 28, 2021


Centella asiatica is a well-established plant in both of the traditional system of medicine in Ayurveda and Unani. In Ayurveda, the plant is reported in the treatment of hyperglycemia and as a blood purifier. The plant is having in vitro antioxidant and free radical scavenging activity, hypoglycemic activity, and cardioprotective effect. Centella asiatica is the chief ingredient in many of the polyherbal formulations used in ayurveda and unani viz. Abana. Centella asiatica has been proved as a good hypoglycemic. The present study was conducted on a 14 day model in which the effect of Centella asiatica extract was observed on STZ induced diabetic rats that were fed with high fat diet (HFD). Diabetes induced by STZ (50 mg/kg) i.p. injection. All the animals were allocated into 7 different groups following two types of dietary regimen. Normal pellet diet (NPD) and high fat diet (HFD) to observe the effects of STZ in presence of each groups except NC. Daily food and water was measured. Hyperlipidemia induced by feeding with HFD to all animal except NC. The parameters for evaluation of antihyperlipidemic and antihyperglycemic activities are the physical parameters and the biochemical estimation. These are blood glucose level, food efficiency ratio, liver weight, heart weight, lipid profile, biochemical marker and histopathological studies of aorta. The diabetic hyperlipidemic group showed marked elevation and the pre-treatment groups showed significant decrease in theses parameters as compared to D-HFD group (p < 0.01). In biochemical estimations various enzymes like Total cholesterol (TC), Triglyceride (TG). The diabetic hyperlipidemic group shows marked elevation and the pre-treatment groups show significant control in theses parameters as compared to D-HFD group (p < 0.01). The result of this study showed that alcoholic extract Centella asiatica (500 mg/kg) has significant antidiabetic and anti hyperlipidemic activity against streptozocin and high fat diet induced diabetic hyperlipidemic rats. All these results were compared and found to be similar with two standard drugs metformin (500 mg/kg) and atorvastatin (10 mg/Kg).

Keywords: Hyperlipidemia; Centella asiatica; Ayurveda


  1. Shaw JE., et al. “Global estimates of the prevalence of diabetes for 2010 and 2030”. Diabetes Research and Clinical Practice 87 (2010): 4-14.
  2. World Health Organization. Global Report on Diabetes. Geneva: World Health Organization (2016).
  3. Mohsina FP., et al. “Evaluation of Anti diabetic activity of Ichnocarpus frutescens”. International Journal in the field of Pharmacy, Biotechnology 2 (2018): 1-12.
  4. Patel Rakesh., et al. “A Review on Role of Natural Phytoconstituents in the Management of Diabetes Mellitus” 51 (2021): 1231-1242.
  6. Bertoli A., et al. “Lipid profile, BMI, body fat distribution and aerobic fitness in men with metabolic syndrome”. Actadiabetologica1 (2003): 130-133
  7. Fazio S and Linton M F. “The role of fibrates in managing hyperlipidemia: mechanisms of action and clinical efficacy”. Current Atherosclerosis Reports2 (2004): 148-157.
  8. Rao Priya Shaival and Rao K Shaival. “Review on Centellaasiatica: A Wonder Drug”. International Journal of Pharmaceutical and Chemical Sciences3 (2012): 1020-1026.
  9. Leung AY and Foster S. “Encyclopedia of Common NaturalIngredients Used in Food, Drugs, and Cosmetics”. 2nd edition. John Wiley and Son, NY (1998): 284.
  11. Ayurveda health benefits of mandukaparni (Centellaasiatica)-gotu kola by Dr. savitasuri 10-Apr- (2013).
  12. V Gayathri., et al. “Anti-diabetic activity of ethanol of Centellaasiatica (L.)Urban (whole plant) in streotozotocin-induced diabetic rats, isolation of an active fraction and toxicity evalution of extract”. International Journal of Medicinal and Aromatic Plants 3 (2011): 278-286.
  13. Lee S J., et al. “Hypolipidemic and hypoglycemic effects of OrostachysjaponicusA. Berger extracts in streptozotocin-induced diabetic rats”. Nutrition 4 (2011): 301-307.
  14. K Srinivasan., et al. “Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening”. Pharmacological Research 52 (2005): 313-320.
  15. C Vijaya., et al. “Lipid lowering activity of ethanolic extract of leaves of Aeglemarmelos (Linn.) in Hyperlipidaemic models of Wistar Albino Rats”. Indian Journal of Experimental Biology 47 (2009): 182-185.
  16. Maiti Rajkumar., et al. “Attenuation of Hyperglycemia and Hyperlipidemia in Streptozotocin- Induced Diabetic Rats by Aqueous Extract of Seed of Tamarindusindica”. Biological and Pharmaceutical Bulletin 7 (2005): 1172-1176.


Citation: Mohd Ayyub., et al. “Effect of Ethanolic Extract of Centella asiatica against Streptozocin and High Fat Diet Induced Diabetes and Hyperlipidemia in Rats". Acta Scientific Pharmaceutical Sciences 5.9 (2020): 70-80.


Copyright: © 2020 Mohd Ayyub., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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