Combined Inhibitory Effect of Sulindac an NSAID and Quercetin an Antioxidant on
Bleomycin-induced Lung Fibrosis in Rats
Ramesh Verma1, Poonam Mehta1, Vishvesh Dalal1, Manish V Patel1 and Suresh Balakrishnan2*
1Department of Toxicology, Jai Research Foundation, Gujarat, India
2Division of Toxicology, Department of Zoology, Faculty of Science, The M.S. University of Baroda, Vadodara, Gujarat, India
*Corresponding Author: Suresh Balakrishnan, Division of Toxicology, Department of Zoology, Faculty of Science, The M.S. University of Baroda, Vadodara, Gujarat, India.
June 23, 2021; Published: August 18, 2021
Idiopathic pulmonary fibrosis is the most prevalent chronic lung disease. Studies have suggested that ROS such as superoxide anion, hydrogen peroxide and hydroxyl radical are major mediators of lung inflammatory processes. So, the study was conducted to evaluate the ameliorative effects of quercetin alone and in combination with sulindac on lung injury induced by bleomycin. Oral administration of quercetin (100 mg/kg/day) or sulindac (20 mg/kg/day) for 20 days, attenuated the severity of bleomycin induced lung injury and fibrosis through decreasing the adverse effect of bleomycin on lung hydroxyproline contents and plasma TNF-α levels alike. However, subtle signs of toxicity still prevailed. Nevertheless, it was noticed that combined low doses of quercetin (50 mg/kg/day) and sulindac (10 mg/kg/day) provided more benefits than full separate doses of each compound on the deleterious effects accompanied bleomycin administration. Therefore, it is pertinent to presume that concurrent administration of quercetin and sulindac has synergistic effect.
Keywords: Idiopathic Pulmonary Fibrosis; Bleomycin; Quercetin; Sulindac; Hydroxyproline
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