Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 9

Vitamin E Improves Sperm Quality of Chlamydia trachomatis Infected Mice

Nasrin Kheradmand1, Seyed Danial Mohammadi2, Negin Nejati3, Arash Babaei1, Fatemeh Ouroujzadeh4 and Maryam Rahimi1*

1Department of Biology, Faculty of Sciences, Malayer University, Malayer, Iran
2Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3Department of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Department of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran

*Corresponding Author: Maryam Rahimi, Department of Biology, Faculty of Sciences, Malayer University, Malayer, Iran.

Received: June 28, 2021; Published: August 04, 2021


Chlamydia trachomatis (CT) is the most dominant sexually transmitted infection of the male genital tract which impairs semen quality and male fertility. Regarding to high DNA fragmentation of sperm in CT infection, it has been proposed that using the antioxidant agents such as vitamin E may ameliorate semen quality of CT infected patients.

The aim of this study is to investigate the effects of vitamin E administration on sperm quality improvement in CT infected mice.

Twenty four adult mice were distributed in four groups: control, CT infected, CT infected + vitamin E (100 mg/kgbody weight/day), and vitamin E (100 mg/kgbody weight/day) groups. Five days after infection induction, animals were treated with vitamin E for 3 weeks. Then animals were killed and the testicles were removed for sperm analysis, gene expression and western blot experiments. Furthermore, serum levels of sexual hormones were evaluated.

CT infection caused a significant reduction in testes weight, testosterone level, and sperm parameters including number, motility, and vitality. Moreover, follicle-stimulating hormone (FSH) level and expression of p53 were significantly higher in CT infected mice in compared with the control group (p < 0.05). Our results showed that sperm parameters, p53 expression, and sexual hormones levels in CT infected + vitamin E group had no significant difference compared with the control group.

Vitamin E can be an effective therapeutic agent to improve sperm parameters in CT infected patients possibly via its antioxidant properties.

Keywords: Chlamydia trachomatis; Sperm Parameters; Vitamin E


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Citation: Maryam Rahimi., et al. “Vitamin E Improves Sperm Quality of Chlamydia trachomatis Infected Mice". Acta Scientific Pharmaceutical Sciences 5.9 (2020): 17-24.


Copyright: © 2020 Maryam Rahimi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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