Design, Synthesis and Antimicrobial Activities Evaluation of 1, 3 Thiazine Derivatives
Khan Sana1*, Singh Gurdeep2 and GN Darwhekar1
1Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, India
2School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
*Corresponding Author: Khan Sana, Acropolis Institute of Pharmaceutical Education and Research, Indore, MP, India.
April 21, 2021; Published: June 23, 2021
Some novel 30 derivatives of 1, 3 thiazine have been designed for Computational studies. This derivatives of 1,3 thiazine were subjected to molecular docking studies against E. coli Glucosamine -6 P Synthase in Complex with Fructose -6 P (PDB ID- 4 AMV) and Crystal structure of Peptide deformylase from Staphylococcus Aureus Complex with Actinonin (PDB ID- 1Q1Y) using Molegro Virtual Docker software. On the basis of docking results 10 derivatives of thiazine were selected and synthesized by the condensation of 2-hydroxy-3- nitro5-chlorochalcones with thiourea and phenylthiourea in ethanol containing aqueous KOH solution. All synthesized compound have been screened for in-vitro evaluation of antimicrobial activities by agar plate techniques. The results indicated that all the synthesized 1, 3 thiazine derivatives shows considerable antimicrobial activities. This study suggested that 1, 3-thiazine derivatives founded to have potent antimicrobial activity against the selected pathogenic organisms and posses more antimicrobial activities on gram negative (E. coli) bacteria than gram positive bacteria (S. aureus). Keywords: 1, 3 thiazine, molecular docking, analysis, characterization, antimicrobial activities, thiourea, phenyl thiourea, gram negative bacteria.
Keywords: 1, 3 Thiazine; Molecular Docking; Analysis; Characterization; Antimicrobial Activities; Thiourea; Phenyl Thiourea; Gram Negative Bacteria
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