Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 5 Issue 7

Forskolin - A Natural Root Extract of Coleus forskohlii

Balaram Ghosh1, Manas Chakraborty2* and Arindam Chakraborty2

1Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and AHS, Banitabla, Uluberia, Howrah, West Bengal, India
2Department of Pharmaceutical Biotechnology, Calcutta Institute of Pharmaceutical Technology and AHS, Banitabla, Uluberia, Howrah, West Bengal, India

*Corresponding Author: Manas Chakraborty, Department of Pharmaceutical Biotechnology, Calcutta Institute of Pharmaceutical Technology and AHS, Banitabla, Uluberia, Howrah, West Bengal, India.

Received: May 06, 2021; Published: June 11, 2021


  Novel drug delivery system is one of the novel approach towards the drug delivery system. Through this, the limitations of traditional drug delivery systems has been addresses. Limited studies have shown that the extract of Coleus forskohlii may helps in weight management. Some randomized double blind placebo- controlled study shows that the effects of the Coleus forskohlii extract with supplementations will be one of the key markers of different metabolic parameters of overweight and obesity. Countries like Africa, UAE, Brazil, coleus forskohlii used as a medicine whereas in India the root tubers of coleus forskohlii plant has been prepared and eaten as a seasoning food and in some part of India it is used a traditional Ayurvedic medicine. There are some chemical studies also indicates that the alcoholic extract of Coleus barbatus root tubes generated in the isolation of labdane diterpene forskolin (Coleonol), which has a great impact in the research of the roles of enzyme adenylate cyclase and cyclic- AMP in human cellular physiology. Diseases like hypertension, asthma, glaucoma as well as some of the certain cancers we can use this compound eventually. Coleus forskohlii root extract used in different drug development studies for proper and better bioavailability which serving superior patients’ compliance. So, this review gives a glimpse of studies of this traditional herb in human welfare.

Keywords: Coleus forskohlii; Forskolin; Placebo Controlled, Bioavailability, Anti-obesity, Coleonol


  1. Kavitha C., et al. “Coleus forskohlii-a comprehensive review on morphology, phytochemistry and pharmacological aspects”. Journal of Medicinal Plants Research4 (2010): 278-285.
  2. Abraham Z., et al. “Cytoplasmic vesicles containing secondary metabolites in the roots of Coleus forskohlii”. Current Science 57 (1988): 1337-1339.
  3. Chakraborty M., et al. “Formulation development studies on gastroretentive floating drug delivery system of Forskolin-a natural root extract of Coleus forskohlii”. Asian Journal of Pharmaceutical and Clinical Research 5 (2012): 165-167.
  4. Patil S., et al. “Performance of genotypes of Coleus forskohlii for growth, yield and essential oil content”. Indian Perfumer 45 (2001): 17-21.
  5. KAgarwal KC and Parks RE. “Forskolin: a potential antimetastic agent”. International Journal of Cancer 32 (1983): 801-804.
  6. Caprioli J and Sears M. “Forskolin lowers intraocular pressure in rabbits, monkeys, and man”. Lancet (1983): 958-960.
  7. Shan Y., et al. “Diterpenes from Coleus forskohlii”. Chemical and Pharmaceutical Bulletin 56 (2008): 52-56.
  8. Burns TW., et al. “Comparative effects of forskolin and isoproterenol on the cyclic AMP content of human adipocytes”. Life Science 40 (1987): 145-154.
  9. Greenway FL., et al. “Topical fat reduction”. Obesity Research 3 (1995): 561S-568S.
  10. Schaneberg BT and Khan IA. “Quantitative analysis of forskolin in Coleus forskohlii (Lamiaceae) by reversed-phase liquid chromatography”. Journal of AOAC International 86 (2003): 467-470.
  11. Ammon HPT and Muller. “Forskolin: from an Ayurvedic Remedy to a Modern Agent”. Planta Medica 51 (1989): 475-476.
  12. Kral G., et al. “Body composition in adipose tissue cellularity before and after jejuno- ileostomy in several obese subjects”. European Journal of Clinical Investigation 7 (1977): 414-416.
  13. Caprioli J and Sears M. “Forskolin lowers intraocular pressure in rabbits, monkeys and man”. Lancet 8331 (1983): 958-960.
  14. Caprioli J., et al. “Forskolin lowers intraocular pressure by reducing aqueous inflow”. Investigative Ophthalmology and Visual Science 25 (1984): 268-277.
  15. De Souza NJ. In: Proceedings of the Third Asian symposium on medicinal plants and species. Colombo, Sri Lanka, UNESCO (1977): 83-92.
  16. Valdes LJ., et al. “Coleus barbatus ( forskohlii) (Lamiaceae) and the potential new drug forskolin (Coleonol)”. Economic Botany 44 (1987): 474-483.


Citation: Manas Chakraborty., et al. “Forskolin - A Natural Root Extract of Coleus forskohlii". Acta Scientific Pharmaceutical Sciences 5.7 (2020): 113-116.


Copyright: © 2020 Manas Chakraborty., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate32%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US