Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 7

Synthesis, Characterization and Application of Norm Encapsulated Zinc Phthalocyanine Nanoparticles as Photo Dynamic Therapeutic Agents

Tarun Mohan1,2*, Hemant Kumar1, L. Krishna Bharat3 and Indrajit Roy1

1Department of Chemistry, University of Delhi, Delhi, India
2Government Degree College, Gairsain, Uttarakhand, India
3Federal State Budgetary Scientific Institution “Federal Scientific Agroengineering Center VIM” (FSAC VIM), Moscow, Russia

*Corresponding Author: Tarun Mohan Department of Chemistry, University of Delhi, Delhi, India. E-mail: tarunmohandu@gmail.com and Indrajit Roy Department of Chemistry, University of Delhi, Delhi, India. E-mail: indrajitroy11@gmail.com

Received: May 25, 2021; Published: June 09, 2021

Abstract

Nanosized organically modified silica (NORM) particles are promising platforms for encapsulating/conjugating active agents for petitions in bioimaging, light activated therapies and drug delivery. Photodynamic therapy (PDT) is an encouraging and significant therapeutic technique in which light is used to activate photosensitizer molecules, that further reacts with molecular oxygen to produce highly reactive and cytotoxic singlet oxygen. Localized PDT can lead to selective killing of malicious cancer cells. Herein, we have synthesized zinc phthalocyanine (ZnPc) encapsulated NORM particles (ZnPc/NORM), in which ZnPc acts as the photosensitizer and NORM particles act as a carrier and also stabilizer of ZnPc. Further characterization of nanoparticles has been done by various techniques to study the morphology, structure and optical properties. ABMDMA dye was used to evaluate the photodynamic property of ZnPc/NORM particles. These nanoparticles have great potential for being a PDT agent as these nanoparticles significantly generate singlet oxygen on irradiation with laser light, along with some hyperthermia (rise in temperature). In vitro studies have been carried out using adenocarcinomic human alveolar basal epithelial (A549) cells to study the anticancer PDT efficacy of ZnPc/NORM.

Keywords: NORM; Zinc Phthalocyanine; Photodynamic Therapy; Hyperthermia; Cell Viability Assay

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Citation

Citation: Tarun Mohan., et al. “Synthesis, Characterization and Application of Norm Encapsulated Zinc Phthalocyanine Nanoparticles as Photo Dynamic Therapeutic Agents". Acta Scientific Pharmaceutical Sciences 5.7 (2020): 82-90.

Copyright

Copyright: © 2020 Tarun Mohan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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