Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 7

Nanosizing of Model Drug: Characterization and Evaluation of Nanosized Model Drug Diffusion through Biomembrane

Sushant Kumar1*, Kamla Pathak1, NV Satheesh Madhav2, Anurag Verma3 and Swarnima Pandey4

1Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, UP, India
2Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India
3Faculty of Pharmacy, Teerthankar Mahaveer University, Moradabad, UP, India
4Goel Institute of Pharmacy & Science, Dr. APJAKT University, Lucknow, India

*Corresponding Author: Sushant Kumar, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, U.P., India.

Received: April 28, 2021; Published: June 03, 2021

Abstract

Background: As the lamotrigine is poorly water soluble drug. The dug was characterized for different physico-chemical properties and nanosized by solvent evaporation sonication technique.

Aims and Objectives: This research was aimed to reduce the model particle size and evaluate the diffusion study.

Methods: In the research work the bath sonication was done at 250 hertz frequency at room temperature. During sonication 25ml of purified water as added slowly drop by drop till turbidity was observed. The obtained residue was then centrifuged for 30 minutes at 4000 rpm for complete recovery of nanosized drug.

Results: Lamotrigine was found to be very soluble in methanol, soluble in phosphate buffer pH7.4 solution. It was found to be sparingly soluble in 0.1MHCl, phosphate buffer, pH 5.8 solutions. The nanosizing of drug particle was confirmed when the number of sonication cycles was increased up to 15 cycles as optimized, the %transmittance was found to increase proportionally.

Conclusion: This diffusion was in significant amount and confirmed that the nanosized drug easily pass through the biomembrane and can be targeted to desired sites in significant amount.

Keywords: Lamotrigine; Nanosizing; SEM Testing; Diffusion; Solubility

References

  1. Madhav NVS., et al. “Formulation and evaluation of Duloxetine loaded bio-nano suspension for brain specificity via acoustic meatus”. SOJ Pharmacy and Pharmaceutical Sciences 1 (2017): 1-5.
  2. Madhav NVS., et al. “Development and evaluation of nanosized aripiprazole-loaded bioflexy films using a biopolymer from Lagenaria sicerariafor brain delivery through orosoft palatal mucosal platform”. Egypt Pharmaceutical Journal 16.1 (2017): 62-68.
  3. Madhav NVS., et al. “A novel potent muco- bioadhesant polymer from seeds of Ricinus communis”. World Journal of Pharmaceutical Sciences 3 (2014): 2154-2165.
  4. Silverstein RM., et al. “Spectroscopic identification of organic compounds”. 6th ed., New Delhi; Wiley India Pvt. Ltd (2010).
  5. Sinko PJ. “Martin’s, Physical pharmacy and pharmaceutical sciences”. 5th Edition, B.I publications Pvt. Ltd, New Delhi (2006).
  6. Richard A., et al. “Solid State Characterization of Pharmaceuticals”. First Edition. Edited by Blackwell Publishing Ltd. Published by Blackwell Publishing Ltd. (2011).
  7. Varshney S., et al. “Development and evaluation of bioflexy films using a novel biopolymer from Ananas cosmosus loaded with nanosized tiagabine”. Egyptian Pharmaceutical Journal1 (2018): 1-12.
  8. Tyagi Y., et al. “Smart innovative approach for designing fluvoxamine loaded bio-nanosuspension for the management of depression". International Journal of Applied Pharmaceutics 1 (2019): 191-197.
  9. Tyagi Y., et al. “Inbuilt novel bioretardant feature of biopolymer isolated from cucumis sativa for designing drug loaded bionanosuspension”. Journal of Drug Assessment1 (2020): 72-81.
  10. Tyagi Y., et al. “Design of selegiline loaded bionanosuspension for the management of depression using novel bioretardant from Manilkara zapota”.Drug Development and Industrial Pharmacy 8 (2019): 1351-1360.
  11. Chatwal G., et al. “Instrumental methods of Chemical Analysis". 5th edition, Himalaya publishing house, New Delhi, 1.1-1.8 (2002): 2.566-2.570.

Citation

Citation: Sushant Kumar., et al. “Nanosizing of Model Drug: Characterization and Evaluation of Nanosized Model Drug Diffusion through Biomembrane". Acta Scientific Pharmaceutical Sciences 5.7 (2020): 34-40.

Copyright

Copyright: © 2020 Sushant Kumar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is October 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US