Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 5 Issue 6

A Study of Hydrogels/em>

Shailee V Tiwari* and Shruti V Dabhade

Department of Pharmaceutical Chemistry, Durgamata Institution of Pharmacy, Parbhani, India

*Corresponding Author: Shailee V Tiwari, Department of Pharmaceutical Chemistry, Durgamata Institution of Pharmacy, Parbhani, India.

Received: March 12, 2021; Published: May 24, 2021

Abstract

  Hydrogels are hydrophilic, crosslinked polymeric structures that can swell in water and can maintain its structure by physical or chemical crosslinking of polymer chain. They are 90% water and permeable to drugs for delivery and encourage controlled delivery. Due to their physicochemical properties and preparation methods hydrogels are applied in large scale engineering and biomedical applications, regenerative medicine. In this article, different types of hydrogels are studied, followed by their preparation methods, classification, physicochemical properties, different characterizations, and their current trends and applications in various fields such as cell culture, clinical surgery, tissue engineering, biosensing, medication delivery and release are discussed.

Keywords: Hydrogels; Applications; Directed Drug Delivery; Drug Discharge

References

  1. Lee KY and Mooney DJ. “Hydrogels for Tissue Engineering”. Chemical Review7 (2001): 1869-1880.
  2. Van der Linden HJ., et al. “Stimulus-sensitive hydrogels and their applications in chemical (micro)analysis”. Analyst 128 (2003): 325-331.
  3. Jen AC., et al. “Hydrogels for cell immobilization”. Biotechnology and Bioengineering4 (1996): 357-364.
  4. Wang K., et al. “Hydrogels as separation agents”. Advances in Polymer Science 2 (1993): 67-79.
  5. Bennett SL., et al. Journal of Cardiac Surgery6 (2003): 494-499.
  6. Sutton C. The Obstetrician and Gynaecologist 7 (2005): 168-176.
  7. Murakami T., et al. “One-pot “click” fabrication of slide-ring gels”. Macromolecules 21 (2015): 7774-77781.
  8. Merino S., et al. “Nanocomposite hydrogels: 3D polymer–nanoparticle synergies for on-demand drug delivery”. ACS Nano 5 (2015): 4686-4697.
  9. Gaharwar AK., et al. “Nanocomposite hydrogels for biomedical applications”. Biotechnology and Bioengineering3 (2014): 441-453.
  10. Balint R., et al. “Conductive polymers: towards a smart biomaterial for tissue engineering”. Acta Biomaterialia 6 (2014): 2341-2353.
  11. Kloxin AM., et al. “Mechanical properties of cellularly responsive hydrogels and their experimental determination”. Advanced Materials31 (2010): 3484-3494.
  12. Gilmore K., et al. “Preparation of hydrogel/conducting polymercomposites”. Polymer Gels and Networks 2 (1994): 135-143.
  13. Sharma K., et al. “Conducting polymer hydrogels and their applications”. Conducting Polymer Hybrids Springer, Cham (2017): 193-221.
  14. Tang Q., et al. “Two-steps synthesis of a poly (acrylate–aniline) conducting hydrogel with an interpenetrated networks structure”. Carbohydrate Polymers3 (2007): 332-336.
  15. Tang Q., et al. “A multifunctional hydrogel with high conductivity, pH-responsive, thermo-responsive and release properties from polyacrylate/polyaniline hybrid”. Carbohydrate Polymers2 (2008): 315-321.
  16. Peppas NA. “Hydrogels in Medicine and Pharmacy”. Fundamentals, CRC Press, BocaRaton, FL. 1986,1,180.
  17. Malcolm B., et al. “Swelling properties of copolymeric hydrogels prepared by gammairradiation”. (1986): 457-475.
  18. Sperinde JJ and LG Griffith. “Control and Prediction of Gelation Kinetics in Enzymatically Cross-Linked Poly (ethylene glycol) Hydrogels”. Macromolecules 33 (2000): 5476-5480.
  19. Peppas NA. “Crystallization of polyvinyl alcohol-water film by slows dehydration”. European Polymer Journal 8 (1976): 495-498.
  20. Burkert S., et al. “Crosslinking of poly (N-vinyl pyrrolidone) films by electron beam irradiation”. Radiation Physics and Chemistry 76 (2007): 1324-1328.
  21. Szepes A., et al. “Characterization and drug delivery behaviour of starch basedhydrogels prepared via isostatic ultrahigh pressure”. Carbohydrate Polymers 72 (2008): 571-575.
  22. Yu H and Xiao C. “Synthesis and properties of novel hydrogels from oxidized Konjac glucomannan crosslinked gelation for in-vitro drug delivery”. Carbohydrate Polymers 72 (2008): 479-489.
  23. Yin Y., et al. “Study of the swelling dynamics with overshooting effect of hydrogels based on sodium alginate-g-acrylic acid”. Carbohydrate Polymers 71 (2008): 682-689.
  24. Kim SW., et al. “Hydrogels: Swelling, drug loading and release”. Pharmaceutical Research3 (1992): 283-290.
  25. Schuetz YB., et al. “A novel thermo responsive hydrogel of chitosan”. European Journal of Pharmaceutics and Biopharmaceutics 68 (2008): 19-25.
  26. Pampaloni F., et al. “The third dimension bridges the gap between cell culture and live tissue”. Nature Reviews Molecular Cell Biology 8 (2007): 839-845.
  27. Yue K., et al. “Synthesis, properties, and biomedical applications of gelatinmethacryloyl (GelMA) hydrogels”. Biomaterials 73 (2015): 254-271.
  28. Nichol JW., et al. “Cell-laden micro engineered gelatin methacrylate hydrogels”. Biomaterials 31 (2010): 5536-5544.
  29. Loessner D., et al. “Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms”. Nature Protocol 11 (2016): 727-746.
  30. Noshadi I., et al. “In vitro and in vivo analysis of visible light crosslinkable gelatin methacryloyl (GelMA) hydrogels”. Biomaterials 5 (2017): 2093-2105.
  31. Meng K., et al. “A Reversibly Responsive Fluorochromic Hydrogel Based on Lanthanide–Mannose Complex”. Advanced Sciences 6 (2019): 1802112.
  32. Zhao X., et al. “Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing”. Nature Communication 9 (2018): 2784.
  33. Maulvi FA., et al. “A review on therapeutic contact lenses for ocular drug delivery”. Drug Delivery 23 (2016): 3017-3026.
  34. Maulvi FA., et al. “In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery. In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery”. Journal of Controlled Release 226 (2016): 47-56.
  35. Li YW and Lu HZ. “Dual Stable Nanomedicines Prepared by Cisplatin-Crosslinked Camptothecin Prodrug Micelles for E_ective Drug Delivery”. ACS Applied Materials and Interfaces 11 (2019): 20649-20659.
  36. Li J. “Self-assembled supramolecular hydrogels based on polymer–cyclodextrin inclusion complexes for drug delivery”. NPG Asian Material 2 (2010): 112.
  37. Moncada-Basualto M. “Supramolecular hydrogels of β-cyclodextrin linked to calcium homopoly-lguluronate for release of coumarins with trypanocidal activity”. Carbohydrate Polymers 204 (2016): 170-181.
  38. Jalalvandi E. “Cyclodextrin -polyhydrazine degradable gels for hydrophobic drug delivery”. Materials Science and Engineering C 69 (2016): 144-153.
  39. Thi TTH. “Oxidized cyclodextrin-functionalized injectable gelatin hydrogels as a new platform for tissue adhesive hydrophobic drug delivery”. RSC Advances 7 (2017): 34053-34062.
  40. Zhang L. “Multifunctional quantum dot DNA hydrogels”. Nature Communication 8 (2017): 381.
  41. Le X. “Fe3+-, pH-, Thermoresponsive Supramolecular Hydrogel with Multi shape Memory Effect”. ACS Applied Materials and Interfaces 9 (2017): 9038-9044.
  42. Cao W. “γ-Ray-Responsive Supramolecular Hydrogel Based on a Diselenide-Containing Polymer and a Peptide”. Angewandte Chemie 125 (2013): 6353-6357.
  43. Liang Y. “A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity”. Biomaterials 32 (2011): 9308-9315.
  44. Alvarez-Lorenzo C. “Bioinspired hydrogels for drug-eluting contact lenses”. Acta Biomaterial 84 (2019): 49-62.
  45. Zhu Q. “Inner layer-embedded contact lenses for pH-triggered controlled ocular drug delivery”. European Journal of Pharmaceutics and Biopharmaceutics 128 (2018): 220-229.
  46. Zhu Q. “Sustained ophthalmic delivery of highly soluble drug using pH-triggered inner layer-embedded contact lens”. International Journal of Pharmaceutics 544 (2018): 100-111.
  47. Segura T. “Materials with fungi-bioinspired surface for efficient binding and fungi-sensitive release of antifungal agents”. Biomacromolecules 15 (2014): 1860-1870.
  48. Kim H. “Synergistically enhanced selective intracellular uptake of anticancer drug carrier comprising folic acid-conjugated hydrogels containing magnetite nanoparticles”. Scientific Report 7 (2017): 41090-41090.
  49. Schlegel PN. “Effective long-term androgen suppression in men with prostate cancer using a hydrogel implant with the GnRH agonist histrelin”. Urology 58 (2001): 578-582.
  50. Wang X. “Vaginal delivery of carboplatin-loaded thermosensitive hydrogel to prevent local cervical cancer recurrence in mice”. Drug Delivery 23 (2016): 3544-3551.

Citation

Citation: Shailee V Tiwari and Shruti V Dabhade. “A Study of Hydrogels". Acta Scientific Pharmaceutical Sciences 5.6 (2020): 86-97.

Copyright

Copyright: © 2020 Shailee V Tiwari and Shruti V Dabhade. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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