Impact of Pharmaceutical Care Services in Health Related Outcomes among Children with Thalassemia
Almana Rodrigues1, Jitha Y1, Merlin Susan Paul1, Sajja Prabhatha Lakshmi1, Juny Sebastian1* and Mandyam Dhati Ravi2
1Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher education and Research, Mysuru, Karnataka, India
2Department of Paediatrics, JSS Medical College and Hospital, JSS Academy of Higher education and Research, Mysuru, Karnataka, India
*Corresponding Author: Juny Sebastian, Lecturer, Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher education and Research, Mysuru, Karnataka, India.
May 10, 2021; Published: May 17, 2021
Background: Thalassemia is a rare disease that pose significant morbidity among the affected individuals due to various reasons such as drug related problems (DRPs), poor knowledge, attitude and practice (KAP) of thalassemia disease and its treatments. These unresolved problems lead to poor medication adherence and there by compromise in quality of life among the thalassemia patients specially children. The current study was conducted to assess the impact of pharmaceutical care services in health related outcomes among Thalassemia patients.
Methods: This was a randomized controlled study conducted at Hematology Clinic, JSS Hospital Mysuru. Eligible subjects were enrolled after taking informed consent randomized to test and control groups. Study participants medical records were assessed for actual or potential DRPs, KAP on thalassemia, HRQoL and medication adherence during the first visit (V1). Standardized education by clinical pharmacist was provided to the test group participants during all the study visits (V2 and V3) while control group participants received a validated information leaflet during first visit (V1) and no further interventions in subsequent visits (V2 and V2). At the end of the study, study participants of both the groups were reassessed for DRPs, KAP, HRQoL and medication adherence.
Results: A total of 48 subjects were consented for the study. The study could significantly decrease the DRPs of the study population in the test group. Also, KAP (p 0.001), HRQoL (p 0.001) and medication adherence (p 0.001) of the test group was significantly improved when compared to the control group study population.
Conclusion: Practicing clinical pharmacists can significantly influence the health related outcomes children with thalassemia by providing different pharmaceutical cares services and individual education to the children and their LAR.
Keywords: HRQoL; KAP; Medication Adherence; PedsQL; Pharmacist’s Education; Thalassemia Patients
- Review of literature. History of thalassemia (2019).
- Galanello R and Origa R. “Beta- thalassemia”. Orphanet Journal of Rare Diseases 11 (2010): 1-15.
- Yolanda S. “Thalassemia prevalence”. News Medical Life Sciences (2019).
- Babu T., et al. “Prescribing patterns and drug related problems (DRPs) in transfusion –dependent paediatric thalassemia patients: A prospective interventional study from a tertiary care hospital in India”. International Journal of Paediatrics and Adolescent Medicine (2020): 1-4.
- Cheerva CA. “Alpha thalassemia”. Medscape.
- Miller ER. “Beta thalassemia”. Kids health from Nemours (2015).
- Neufeld JE. “Oral chelatorsdeferasirox and deferiprone for transfusional iron overload in thalassemia major”. Blood 9 (2006): 3436-3441.
- Ansari SH., et al. “Quality of life in patients with thalassemia major”. Iranian Journal of Pediatric Hematology and Oncology2 (2014): 57.
- Han KE., et al. “Thaleaaemia in the outpatient department of the yangon children's hospital in myanmar. knowledge, attitude and practice in relation to thalassemia”. Southeast Asian Journal of Tropical Medicine and Public Health 2 (2013): 269-272.
- National ethical guidelines for biomedical and health research involving human participants. Indian council of medical research. New Delhi: Director-General (2018): 50-55.
- Basu M. “A study on knowledge, attitude and practice about thalassemia among general population in outpatient department at a tertiary care hospital of Kolkata”. Journal of Preventive Medicine and Holistic Health 1 (2015): 6-13.
- Saxena A., et al. “Knowledge, Practice and Experiences of parents with the thalassemic child”. International Journal of Contemporary Pediatrics5 (2017): 16302-16333.
- Panda K., et al. “Adherence to deferasirox among beta thalassemia major children-A cross-sectional study in tertiary care hospital”. Deferasirox Adherence Among Thlassemic Children1 (2017): 38-41.
- Wahyuni SM., et al. “Quality of life assessment of children with thalassemia”. Paediatrica Indonesian3 (2011): 163-169.
- Caocci G., et al. “Health related quality of life in middle eastern children with beta thalassemia”. BMC Blood Disorder 2 (2012): 120-134.
- Kotzeva A., et al. “Health Related Quality of Life of patients with beta thalassemia”. Value in Health3 (2018): 341-381.
- Ibrahim AY. “Quality of Life Among Thalassemia Children Patients in the Gaza Strip”. American Journal of Nursing Science3 (2016): 106-113.
- Imani E., et al. “Comparison quality of life in patients with thalassemia major based on participating in group activities, Bandar Abbas”. Scientific Journal of Iran Blood Transfus Organ 2 (2013): 198-206.
- Shakib AJ., et al. “Health Related Quality of Life in beta thalassemia major children in North Iran”. Iranian Journal of Blood and Cancer4 (2019): 108-111.
- Arian M., et al. “Health Related Quality of Life in beta thalassemia major patients assessed by 36 items short health survey: A meta analysis”. Quality of Life Research1 (2019): 321-334.
- Samsamipour M., et al. “Health Related quality of life in young adult with beta thalassemia major”. Scientific Journal of Nursing, Midwifery and Paramedical Faculty4 (2019): 66-75.
- Smeltzer SC., et al. “Bruner and Suddharth’s textbook of Medical-Surgical nursing”. 12.1 (2008).
- Ishaq F., et al. “Awareness among parents of Beta Thalassemia major patients regarding prenatal diagnosis and pre marital screening”. Journal of College Physicians and Surgeons Pakistan 4 (2012): 218-221.
- Moghaddam EM., et al. “High school knowledge and attitude towards thalassemia in Southern Iran”. International Journal of Hematology-oncology and Stem Cell Research1 (2014): 24-30.