Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 6

Cholesterol-lowering Effects and Safety Assessment of Lactobacillus spp. In Vivo and In Vitro Testing for Human Use as Probiotic from Dairy Product in Egypt

Mostafa G Fadl1* and Zenat Kamel Mohamed2

1Nuclear Materials Authority, Cairo, Egypt
2Professor, Faculty of Science, Microbiology and Botany Department, Cairo University, Giza Square, Cairo Egypt

*Corresponding Author: Mostafa G Fadl, Nuclear Materials Authority, Cairo, Egypt.

Received: March 22, 2021; Published: May 20, 2021


  The toxicity profile may be strain dependent and among Lactobacilli, one of the most important genus of LAB (Lactic acid bacteria) Further in vivo studies are necessary, and this study focused on the safety, health and growth performance of mice receiving these two strains. The aim of the present investigation is to characterize a number of metabolic properties of Lactobacillus and enhance the understanding of its influence on bacterial metabolism and gut function beside the ability to hydrolyze bile salts Using primer for bile salt hydrolysis gene to confirm probiotic character of superior isolates , the present study showed the isolates meet several function features to be considered as suitable probiotic for application in food fermentation and the isolated bacteria able to tolerate acidic medium and bile salt a favorable enzymatic movement and no hemolytic movement adjacent to has been included within the determination criteria for probiotic strains with cholesterol-lowering impacts, so we consider it awesome potential probiotic character and secure for human utilize.

Keywords: Safety Assessment; Lactobacillus; Enzymatic Activity; Probiotic


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Citation: Mostafa G Fadl and Zenat Kamel Mohamed. “Cholesterol-lowering Effects and Safety Assessment of Lactobacillus spp. In Vivo and In Vitro Testing for Human Use as Probiotic from Dairy Product in Egypt". Acta Scientific Pharmaceutical Sciences 5.6 (2020): 27-38.


Copyright: © 2021 Mostafa G Fadl and Zenat Kamel Mohamed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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