Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 5 Issue 6

From Mechanisms to Clinical Trials: Maslinic Acid, a Promising Modern Anti-inflammatory Drug?

Jiahui Liu, Lei Yu and Hua Li*

Department of Oncology, The General Hospital of Western Theater Command, China

*Corresponding Author: Hua Li, Department of Oncology, The General Hospital of Western Theater Command, China.

Received: March 08, 2021; Published: May 20, 2021

Abstract

  Chronic inflammation plays an essential role in various severe diseases and has become a main cause of death. Anti-inflammation medications for prevention and treatment of inflammation-related diseases are urgent. Maslinic Acid (MA), a pentacyclic triterpene abundant in olives, has been on our plates for years, but its anti-inflammatory mechanism has been clarified clearly until the last five years. Subsequently, the anti-inflammatory effect of MA for inflammation-related diseases was verified in pre-clinical and clinical studies. The MA studies reported in PubMed, Web of Science, Google Scholar, Baidu Scholar, CNKI, Science Direct, Springer and Wiley databases or registered in clinical trial management platforms were searched with the following key terms: maslinic acid, inflammation, inflammatory disease, pharmacological activity. This review from the perspective of medicine combed the anti-inflammation molecular mechanisms of MA and assessed the recent clinical trials, revealing the potential therapeutic use of Maslinic Acid as a new drug for the prevention and treatment of chronic inflammation-related diseases. These results should encourage more pre-clinical and clinical studies with stringent design and more strong evidence to accelerate the drug development MA.

Keywords: Maslinic Acid; Chronic Inflammation; NF-κB

References

  1. J Sabatino., et al. “B cells in autoimmune and neurodegenerative central nervous system diseases”. Nature Reviews Neuroscience12 (2019): 728-745.
  2. J Li., et al. “Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S”. Journal of the American College of Cardiology19 (2020): 2181-2193.
  3. JA French., et al. “Clinical studies and anti-inflammatory mechanisms of treatments”. Epilepsia 58 (2017): 69-82.
  4. H He., et al. “Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities”. The Journal of Allergy and Clinical Immunology (2020).
  5. A Rajopadhye and AS Upadhye. “Estimation of Bioactive Compound, Maslinic Acid by HPTLC, and Evaluation of Hepatoprotective Activity on Fruit Pulp of Ziziphus jujuba Mill. Cultivars in India”. Evidence-Based Complementary and Alternative Medicine 2016 (2016): 4758734.
  6. E Sanchez-Rodriguez., et al. “Effects of Virgin Olive Oils Differing in Their Bioactive Compound Contents on Biomarkers of Oxidative Stress and Inflammation in Healthy Adults: A Randomized Double-Blind Controlled Trial”. Nutrients3 (2019).
  7. BN Mkhwanazi., et al. “Triterpene derivative improves the renal function of streptozotocin-induced diabetic rats: a follow-up study on maslinic acid”. Renal Failure1 (2019): 547-554.
  8. CM Martin-Navarro., et al. “Amoebicidal Activity of Caffeine and Maslinic Acid by the Induction of Programmed Cell Death in Acanthamoeba”. Antimicrobe Agents Chemotherapy6 (2017).
  9. X Huang., et al. “Continuous separation of maslinic and oleanolic acids from olive pulp by high-speed countercurrent chromatography with elution-extrusion mode”. Journal of Separation Science11 (2019): 2080-2088.
  10. G Lozano-Mena., et al. “Identification of gut-derived metabolites of maslinic acid, a bioactive compound from Olea europaea L”. Molecular Nutrition and Food Research 9 (2016): 2053-2064.
  11. M Sanchez-Gonzalez., et al. “Population pharmacokinetics of maslinic acid, a triterpene from olives, after intravenous and oral administration in rats”. Molecular Nutrition and Food Research 10 (2014): 1970-1979.
  12. R de la Torre., et al. “Pharmacokinetics of maslinic and oleanolic acids from olive oil - Effects on endothelial function in healthy adults. A randomized, controlled, dose-response study”. Food Chemistry 322 (2020): 126676.
  13. K Shimazu., et al. “The Anti-Arthritis Effect of Olive-Derived Maslinic Acid in Mice is Due to its Promotion of Tissue Formation and its Anti-Inflammatory Effects”. Molecular Nutrition and Food Research 63 (2019): e1800543.
  14. E Ampofo., et al. “Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression”. Molecular Nutrition and Food Research1 (2019): 6119.
  15. K Shimazu., et al. “The Anti-Arthritis Effect of Olive-Derived Maslinic Acid in Mice is Due to its Promotion of Tissue Formation and its Anti-Inflammatory Effects”. Molecular Nutrition and Food Research3 (2019): e1800543.
  16. S Fukumitsu., et al. “Anti-inflammatory and anti-arthritic effects of pentacyclic triterpenoids maslinic acid through NF-κB inactivation”. Molecular Nutrition and Food Research2 (2016): 399-409.
  17. Y Chen., et al. “Maslinic acid prevents IL-1β-induced inflammatory response in osteoarthritis via PI3K/AKT/NF-κB pathways”. Journal of Cellular Physiology3 (2020): 1939-1949.
  18. Yy Wang., et al. “Maslinic acid protects against lipopolysaccharide/D-galactosamine-induced acute liver injury in mice”. Microbial Pathogenesis 119 (2018): 49-53.
  19. W Lee., et al. “Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1”. 9.2 (2020): 106.
  20. J Darnell., et al. “Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins”. Science (New York, N.Y.)5164 (1994): 1415-1421.
  21. J Cho., et al. “Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate”. Oncotarget36 (2015): 39292-306.
  22. X Qin., et al. “Maslinic acid protects vascular smooth muscle cells from oxidative stress through Akt/Nrf2/HO-1 pathway”. Molecular and Cellular Biochemistry 390 (2014): 61-67.
  23. E Ampofo., et al. “Maslinic acid alleviates ischemia/reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression”. Scientific Reports1 (2019): 6119.
  24. F Li., et al. “Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress”. Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie 95 (2017): 904-913.
  25. K Mokhtari., et al. “Maslinic Acid, a Triterpene from Olive, Affects the Antioxidant and Mitochondrial Status of B16F10 Melanoma Cells Grown under Stressful Conditions”. Evidence-Based Complementary and Alternative Medicine 2015 (2015): 272457.
  26. MJ Morgan., et al. “Crosstalk of reactive oxygen species and NF-|kappa.|B signaling”. Cell Research 21 (2011): 103-115.
  27. Y Yang., et al. “Maslinic Acid Protected PC12 Cells Differentiated by Nerve Growth Factor against β-Amyloid-Induced Apoptosis”. Journal of Agricultural and Food Chemistry47 (2015): 10243-10249.
  28. AHS A., et al. “Maslinic acid ameliorate electrolytes, membrane bound ATPases, antioxidants and histopathology in isoprenaline attenuated myocardial toxicity in rats”. Journal of King Saud University - Science1 (2020): 1055-1059.
  29. A Shapouri-Moghaddam., et al. “Macrophage plasticity, polarization, and function in health and disease”. Journal of Cellular Physiology9 (2018): 6425-6440.
  30. C Sánchez-Quesada., et al. “Maslinic Acid enhances signals for the recruitment of macrophages and their differentiation to m1 state”. Evidence-Based Complementary and Alternative Medicine : eCAM 2015 (2015): 654721.
  31. H Wee., et al. “Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages”. BMC Complementary Medicine and Therapies1 (2020): 91.
  32. W Yap., et al. “Inhibition of Human Group IIA-Secreted Phospholipase A2 and THP-1 Monocyte Recruitment by Maslinic Acid”. Lipids10 (2016): 1153-1159.
  33. S Phang., et al. “Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis”. Vascular Pharmacology (2020): 106675.
  34. T de Brum., et al. “Ethnopharmacological study and topical anti-inflammatory activity of crude extract from Poikilacanthus glandulosus (Nees): Ariza leaves”. Journal of Ethnopharmacology 193 (2016): 60-67.
  35. N Esser., et al. “Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease”. Expert Opinion on Investigational Drugs 3 (2015): 283-307.
  36. JA Howell and GL Bidwell. “Targeting the NF-κB pathway for therapy of ischemic stroke”. Therapeutic Delivery 2 (2020): 113-123.
  37. F Zhang., et al. “β-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund's adjuvant-induced arthritis in rats: involvement of NF-кB and HO-1/Nrf-2 pathway”. Drug Delivery1 (2020): 1329-1341.
  38. R Freitas and CAM Fraga. “NF-kappaB-IKKbeta Pathway as a Target for Drug Development: Realities, Challenges and Perspectives”. Current Drug Targets16 (2018): 1933-1942.
  39. I Pavel., et al. “Assessment of the Antiangiogenic and Anti-Inflammatory Properties of a Maslinic Acid Derivative and its Potentiation using Zinc Chloride”. International Journal of Molecular Sciences11 (2019).
  40. W Lee., et al. “Inhibitory functions of maslinic acid, a natural triterpene, on HMGB1-mediated septic responses”. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 69 (2020): 153200.
  41. C Claro-Cala., et al. “Pomace Olive Oil Concentrated in Triterpenic Acids Restores Vascular Function, Glucose Tolerance and Obesity Progression in Mice”. Nutrients2 (2020).
  42. C Liou., et al. “Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway”. FASEB Journal : official publication of the Federation of American Societies for Experimental Biology11 (2019): 11791-11803.
  43. KC Lai., et al. “Maslinic Acid Enhances Immune Responses in Leukemic Mice Through Macrophage Phagocytosis and Natural Killer Cell Activities In Vivo”. In Vivo1 (2019): 65-73.
  44. Z Wang., et al. “Asiatic acid and maslinic acid attenuated kainic acid-induced seizure through decreasing hippocampal inflammatory and oxidative stress”. Epilepsy Research 139 (2018): 28-34.
  45. Q Wei., et al. “Maslinic Acid Inhibits Colon Tumorigenesis by the AMPK-mTOR Signaling Pathway”. Journal of Agricultural and Food Chemistry15 (2019): 4259-4272.
  46. S Fukumitsu., et al. “Maslinic acid in olive fruit alleviates mild knee joint pain and improves quality of life by promoting weight loss in the elderly”. Journal of Clinical Biochemistry and Nutrition3 (2016): 220-225.
  47. S Fukumitsu., et al. “Maslinic acid improves quality of life by alleviating joint knee pain in the elderly: results from a community-based pilot study”. Journal of Clinical Biochemistry and Nutrition1 (2017): 67-73.
  48. J Yoon., et al. “Evaluation of maslinic acid with whole-body vibration training in elderly women with knee osteoarthritis”. PLoS One3 (2018): e0194572.
  49. N Nagai., et al. “Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly”. Journal of Clinical Biochemistry and Nutrition3 (2019): 224-230.
  50. S Biel., et al. “The NUTRAOLEOUM Study, a randomized controlled trial, for achieving nutritional added value for olive oils”. BMC Complementary and Alternative Medicine1 (2016): 404.

Citation

Citation: Hua Li., et al. “From Mechanisms to Clinical Trials: Maslinic Acid, a Promising Modern Anti-inflammatory Drug?". Acta Scientific Pharmaceutical Sciences 5.6 (2020): 17-26.

Copyright

Copyright: © 2020 Hua Li., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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