From Mechanisms to Clinical Trials: Maslinic Acid, a Promising Modern Anti-inflammatory Drug?
Jiahui Liu, Lei Yu and Hua Li*
Department of Oncology, The General Hospital of Western Theater Command, China
*Corresponding Author: Hua Li, Department of Oncology, The General Hospital of Western Theater Command, China.
March 08, 2021; Published: May 20, 2021
Chronic inflammation plays an essential role in various severe diseases and has become a main cause of death. Anti-inflammation medications for prevention and treatment of inflammation-related diseases are urgent. Maslinic Acid (MA), a pentacyclic triterpene abundant in olives, has been on our plates for years, but its anti-inflammatory mechanism has been clarified clearly until the last five years. Subsequently, the anti-inflammatory effect of MA for inflammation-related diseases was verified in pre-clinical and clinical studies. The MA studies reported in PubMed, Web of Science, Google Scholar, Baidu Scholar, CNKI, Science Direct, Springer and Wiley databases or registered in clinical trial management platforms were searched with the following key terms: maslinic acid, inflammation, inflammatory disease, pharmacological activity. This review from the perspective of medicine combed the anti-inflammation molecular mechanisms of MA and assessed the recent clinical trials, revealing the potential therapeutic use of Maslinic Acid as a new drug for the prevention and treatment of chronic inflammation-related diseases. These results should encourage more pre-clinical and clinical studies with stringent design and more strong evidence to accelerate the drug development MA.
Keywords: Maslinic Acid; Chronic Inflammation; NF-κB
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