Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 2

Formulation Development and Characterization of Levocabastine Hydrochloride Ophthalmic Suspension

Debashish Ghose1*, Ch Niranjan Patra2, Suryakanta Swain3 and Bikash Ranjan Jena4

1Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Berhampur, Biju Patnaik University of Technology, Rourkela, Odisha, India
2Department Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Berhampur, Biju Patnaik University of Technology, Rourkela, Odisha, India
3School of Health Sciences, Department of Pharmaceutical Science, The Assam Kaziranga University, Assam, India
4School of Pharmacy and Life Science, Centurion University of Technology and Management, Bhubaneswar, Odisha, India

*Corresponding Author: Debashish Ghose, Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Berhampur, Biju Patnaik University of Technology, Rourkela, Odisha, India.

Received: December 30, 2020; Published: January 28, 2021

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Abstract

Background: In the present study, an attempt was made to develop and evaluate the ophthalmic suspension containing levocabastine hydrochloride.

Objective: The current research objective's rationale was to develop and assess ophthalmic suspension containing antihistamine to improve corneal penetration with corneal tissues and obtain therapeutic efficiency. Recently, ophthalmic drug delivery has become the modern pharmaceutical design standards and intensive research for achieving better drug product effectiveness, reliability, and safety. Topical medication by ocular drug delivery will continue to account for the largest share (up to 90%).

Methods: The prepared ophthalmic suspension had a minimum concentration of preservative preparation in appropriate packaging material. FTIR and UV spectrum of API was found as per specification. The individual IR spectra of the pure drug and the combination spectra of the drugs and other excipients indicated no interaction between API and other excipients than the infrared spectrum of the pure drug as all available group frequencies were present.

Results: The pH of all formulations was satisfactory in the range of 6.0-8.0; thus, there would be no irritation to the patient upon administration of the formulation. The particle size analysis revealed that the particles were in range, and all the formulations showed ideal surface morphology. All the formulations showed osmolality within the range, i.e., 250-500 mOsm/kg.

Conclusion: Finally it was confirmed that formulations of antihistamine ophthalmic suspension remained more stable at ambient temperature (25°C) and relative humidity (40%) as compared to other stability conditions as per ICH guidelines.

Keywords: Corneal Penetration; FTIR; Osmolality; Ambient Temperature; Relative Humidity

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References

  1. Hwang SJ., et al. “Ocular drug delivery system”. Pharmazie 58 (2003): 38-43.
  2. Vanquez MZ., et al. “Influence of technological variables on release of drugs from hydrophilic matrices”. Drug Development and Industrial Pharmacy 18 (1992): 1355-1375.
  3. Dahl TC., et al. “Influence of physico-chemical properties of hydroxypropyl methyl cellulose in naproxen release from sustained release matrix tablets”. Journal of Controlled Release 14 (1990): 1-10.
  4. Diao Y., et al. “Development and pharmacokinetic study of miocamycin sustained release Ocular drug delivery system”. Acta Pharmaceutica Sinica 26 (1991): 695-700.
  5. Du K. et al. “Eye drops of zomepirac sodium with cellulose acetate”. Journal of Pharmaceutical Sciences 60 .1 (1989): 276-278.
  6. Abrahamsson B., et al. “In-vitro and in-vivo erosion of two different hydrophilic Ocular drug delivery system”. European Journal of Pharmaceutics and Biopharmaceutics 1 (1998): 69-75.
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Citation

Citation: Debashish Ghose., et al. “Formulation Development and Characterization of Levocabastine Hydrochloride Ophthalmic Suspension". Acta Scientific Pharmaceutical Sciences 5.2 (2020): 51-56.




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Acceptance rate32%
Acceptance to publication20-30 days
Impact Factor0.759

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