Abstract

  Condensation of 1,2-diaminopropane with acetone in the presence of quantitative amount of perchloric acid, yielded a 14-membered octamethyl tetraazamacrocyclic dihydroperchlorate salt, Me₈[14]diene.2HClO₄ (L.2HClO₄), which on extraction with chloroform at pH above 12 produced free ligand, L. The reaction between nickel(II) nitrate hexahydrate and the free ligand L resulted in a five coordinated square pyramidal light violet complex [NiL(NO₃)](NO₃). Moreover some substituted nickel(II) salts, Ni(NCS)₂, NiCl₂, NiBr₂, NI₂ and Ni(NO₂)₂ prepared in solution (with a possibility of existence of negligible amount of NO₃^- ion) by the interaction of nickel(II) nitrate hexahydrate with KX (X=SCN, Cl, Br or I) and NaNO₂ respectively on reactions with the concerned ligand L furnished orange yellow [NiL](SCN)₂ and light pink [NiL(NCS)](SCN), light purple [NiLCl]Cl, brownish [NiL]Br₂ and light purple [NiLBr]Br, light purple [NiLI]I and light pink [NiL(NO₂)](NO₃) respectively. Among them, [NiL(NCS)](SCN), [NiLCl]Cl, [NiLBr]Br, [NiLI]I and [NiL(NO₂)](NO₃) were analysed as five coordinated square pyramidal and [NiL](SCN)₂ and [NiL]Br₂ as four coordinated square planar in geometry. All these complexes have been characterized on the basis of analytical, spectroscopic, conductometric and magnetochemical data. The antimicrobial activities of the ligand and its new nickel(II) complexes have been evaluated against some selected gram positive and gram negative bacteria.

Keywords: Tetraazamacrocyclic Ligand; Nickel(II) Complexes; Spectral Analysis; Antibacterial Evaluation

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Citation

Citation: Tapashi Ghosh Roy., et al. “Synthesis, Characterization and Antibacterial Evaluation of Some New Nickel(II) Complexes of a Tetraazamacrocycle". Acta Scientific Pharmaceutical Sciences 5.1 (2021): 60-69.

Copyright

Copyright: © 2021 Tapashi Ghosh Roy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.