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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 1

Nature of Wriggling Action of the Filarial Parasite Setatia digitata

Jayakumar K1*, Dhanya N V2, Sony Peter3 and Sree Padma Priya S4

1Professor and Head, Department of Biochemistry, PMS College of Dental Science and Research, Thiruvanthapuram, Kerala, India
2Reader, Department of Biochemistry, Sri Sankara Dental College, Thiruvanthapuram, Kerala, India
3Senior Lecturer, Department of Biochemistry, PM S College of Dental Science and Research, Thiruvanthapuram, Kerala, India
4Reader, Department of Biochemistry, Sree Mookambika Institute of Dental Sciences, Kulasekhram, Tamilnadu, India

*Corresponding Author: Jayakumar K, Professor and Head, Department of Biochemistry, PMS College of Dental Science and Research, Thiruvanthapuram, Kerala, India.

Received: November 17, 2020; Published: December 10, 2020

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Abstract

  Setaria digitata, a cattle filarial parasite, is always in constant motion called the wriggling movement. It is known to take up oxygen even in presence of cyanide. One of the partial reduction products of oxygen formed in the parasite is H202, generated by the parasite specific quinol oxidase called alternative oxidase. The wriggling movement as well as the activity of the parasite specific quinol oxidase and formation of H202 was found to be SHAM sensitive. The wriggling movement was also found to be inhibited by iodoacetate a specific inhibitor of SH groups, showing the involvement of SH groups movement of the parasite. Under in vitro conditions H2O2 was found to increase the wriggling movement of the parasite and the increase was found to be reversed in presence of added catalase. These findings definitely suggest that the wriggling movement of S. digitata is associated with the reduction of oxygen. The process appears to be maintained by the hemoglobin, GSH/GSSG system and the SHAM sensitive quinol oxidase activity.

Keywords: Setaria digitata,; Wriggling Action; Hydrogen Peroxide; Alternative Oxidase

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References

  1. Hawking F. “Diethylcarbamazine. A review of the literature with special reference to its pharmacodynamics, toxicity, and use in the therapy of Onchocerciasis and other filarial infections”. WHO/ONCHO (1978): 78.142.
  2. Kaleysa Raj R., et al. “Oxidative activites in mitochondrial like paricles from Setaria digitata , a filarial paraite”. Biochemistry Journal 256 (1988): 559-609.
  3. Santhamma K R and KaleysaRaj R “Quinone mediated electron transport system in the filarial parasite Setaria digitata”. Biochemical Biophysical Research Communications1 (1991): 386-392.
  4. R Abilash Kumar., et al. “Presence of alternative oxidase activity in the mitochondrial like particles from the filarial parasite Setaria digitata”. Journal of Parasitic Diseases 1 (2000): 27-30.
  5. S Mohan., et al. “The adult specific ubiquinone Q8 functions as an antioxidant in the filarial parasite, Setaria digitata”. Biochemical and Biophysical Research Communications 4 (2001): 949-953.
  6. S Mohan., et al. “Effect of DEC on scavenger enzymes and lipid per oxidation in Setaria digitata”. Biomedicine 20 (2000): 37-42.
  7. Mohan S. “Investigations on the antioxidant systems of the filarial parasite Setaria digitata”. Ph D Thesis submitted to the University of Kerala (2002).
  8. Santhamma K R and Kaleysa Raj R. “Quinone mediated ATP production in the Filarial Parasite Setaria digitata”. Biochemical Biophysical Research Communications 167 (1990): 568-574.
  9. Abhilash Kumar R and Kaleysa Raj R. “Presence and formation of heme and occurance of certain heme proteins in the filarial parasite Setaria digitata”. Biochemical and Biophysical Research Communications 253 (1998): 49-52.
  10. Sivan VM and Kaleysa Raj R. “Quinone analogue irrecoverably paralyses the filarial parasiteSetaria digitata invitro”. Biochemical Biophysical Research Communications 256 (1999): 81-83.
  11. Zachariah T J and Kaleysa Raj R. “Effect of Diethyalcarbamaizine on lipid metabolism of Setaria digitata”. Indian Journal of Medical Research 83 (1986): 41-52.
  12. Bryant C and Behm C. In: “Biochemical Adaptation in Parasites”, Chapmanand Hall, London. (1989): 51-69.
  13. Sugunan VS and Kaleysa Raj R. “Origin of Biologically active excretory secretory materials from Setaria digitata”. Current Science 55 (1986): 331-533.
  14. Skulachev VP. “Role of uncoupled and non-coupled oxidations inmaintenance of safely low levels of oxygen and its one-electron reluctant”. Quarterly Reviews of Biophysics 29 (1996): 169-202.
  15. , et al. “Solublization of the alternative oxidase of cuukoo-pint (Arunmaeulatum) mitochondria”. Biochemical Journal (1985): 228. 309-318.
  16. Antony L Moore., et al. “Control of oxidative phosphorylation in plant mitochondria the role of nonphosphorylating pathways” . Biochemical Biophysical Acta (1991): 121-140.
  17. Denis P Maxwell. “The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells”. Proceedings of National Academy of Sciences14 (1999): 8271-8276.
  18. Rafi M M and Kaleysa Raj R. “Phosphoenolpyruvate-Sucinate-glyoxalate Pathway in the filarial parasite Setaria digitata”. Journal of Biosciences3 (1991): 121-126.
  19. Ajitha Kumari G., et al. “Biosynthesis of Isoperinoid compounds in the cattle filarial parasite Setariadigitata”. Biochemical Biophysical Research Communications 205 (1994): 24-29.
  20. Unnikrishnan LS and Kaleysa Raj R. “Transhydrogenase Activites and malate dismutation linked to Fumarate Reductase System in the Filarial Parasite Setaria digitata”. International Journal of Parasitology 25 (1995): 779-784.
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Citation

Citation: Jayakumar K.,et al. “Nature of Wriggling Action of the Filarial Parasite Setatia digitata" Acta Scientific Pharmaceutical Sciences 5.1 (2020): 04-08.




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