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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 1

Nature of Wriggling Action of the Filarial Parasite Setatia digitata

Jayakumar K1*, Dhanya N V2, Sony Peter3 and Sree Padma Priya S4

1Professor and Head, Department of Biochemistry, PMS College of Dental Science and Research, Thiruvanthapuram, Kerala, India
2Reader, Department of Biochemistry, Sri Sankara Dental College, Thiruvanthapuram, Kerala, India
3Senior Lecturer, Department of Biochemistry, PM S College of Dental Science and Research, Thiruvanthapuram, Kerala, India
4Reader, Department of Biochemistry, Sree Mookambika Institute of Dental Sciences, Kulasekhram, Tamilnadu, India

*Corresponding Author: Jayakumar K, Professor and Head, Department of Biochemistry, PMS College of Dental Science and Research, Thiruvanthapuram, Kerala, India.

Received: November 17, 2020; Published: December 10, 2020

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Abstract

  Setaria digitata, a cattle filarial parasite, is always in constant motion called the wriggling movement. It is known to take up oxygen even in presence of cyanide. One of the partial reduction products of oxygen formed in the parasite is H202, generated by the parasite specific quinol oxidase called alternative oxidase. The wriggling movement as well as the activity of the parasite specific quinol oxidase and formation of H202 was found to be SHAM sensitive. The wriggling movement was also found to be inhibited by iodoacetate a specific inhibitor of SH groups, showing the involvement of SH groups movement of the parasite. Under in vitro conditions H2O2 was found to increase the wriggling movement of the parasite and the increase was found to be reversed in presence of added catalase. These findings definitely suggest that the wriggling movement of S. digitata is associated with the reduction of oxygen. The process appears to be maintained by the hemoglobin, GSH/GSSG system and the SHAM sensitive quinol oxidase activity.

Keywords: Setaria digitata,; Wriggling Action; Hydrogen Peroxide; Alternative Oxidase

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Citation

Citation: Jayakumar K.,et al. “Nature of Wriggling Action of the Filarial Parasite Setatia digitata" Acta Scientific Pharmaceutical Sciences 5.1 (2020): 04-08.




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