Abstract

  The use of biodegradable polymers as drug carriers increases the drug entrapment efficiency and contributes to the sustained release action of the formulation. The purpose of this study was to prepare and evaluate a sustained release Gelatin-Sodium Alginate biodegradable polymeric implant containing Levothyroxine Sodium as a model drug. Heating and congealing methods were used for the preparation of implants in various ratios of Gelatin and Sodium Alginate (70:30, 80:20 and 90:10 % w/w). The prepared implants were exposed to formaldehyde for different time periods, (6hrs, 12hrs and 24hrs) for hardening. The formulated implants were evaluated for weight variation, thickness, presence of free formaldehyde, and in vitro release studies. The interactions between the drug and polymer, good surface integrity, and compatibility have been studied using SEM and DSC. The implant formulated with 80:20 % w/w Gelatin-Sodium Alginate ratio and hardened for 24 hours were found to produce the maximum sustained action for 30 days, and none of the implants contained formaldehyde. The effects of four different excipients with 80:20 ratio were also studied on drug loading efficiency and drug release profile. The drug loading efficiency and drug release were found to be significantly influenced by the addition of different excipients (Stearic Acid > GMS > PEG > Drug only > Cetyl) and variation in hardening times. The results of the in-vitro dissolution study were fitted to different kinetic models to evaluate the kinetic data. The kinetic release data were determined by finding the best fit of the release data to these models. Implants were found to follow both the Higuchi model and Korsmeyer-Peppas model of kinetics with the variation in polymer ratio. Therefore, drug release from the implants implies that a combination of diffusion and erosion contributes to the control of drug release.

Conclusion: Considering the multiple responsibilities of the family nurse, this plan should be implemented.

Keywords: Biodegradable Implant; Gelatin; Sodium Alginate; Levothyroxine Sodium

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Citation

Citation: Anil Giri., et al. “Effect of Biodegradable Polymer on the Release Pattern of Levothyroxine Sodium Implant". Acta Scientific Pharmaceutical Sciences 4.12 (2020): 50-57.

Copyright

Copyright: © 2020 Anil Giri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.