Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 11

Search for Natural Alkaloids as SARS-CoV-2 Proteas and RdRp Inhibitors: A Docking-Based Study

Abhrajit Bag1 and Arijit Bag2*

1Malancha Shishu Shiksha Niketan, Bara Jaguli, West Bengal, India
2Department of Applied Science, Maulana Abul Kalam Azad University of Technology, West Bengal, India

*Corresponding Author: Arijit Bag, Department of Applied Science, Maulana Abul Kalam Azad University of Technology, West Bengal, India.

Received: August 24, 2020; Published: October 28, 2020

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Abstract

  To find an immediately applicable drug for the treatment of COVID-19 positive patients, a plausible life cycle of this virus is proposed from the analysis of a few case reports. Based on this proposal and symptomatic similarities, a few common drug-molecules are tested as a protease inhibitor and RNA dependent RNA polymerase (RdRp) inhibitor of SARS-CoV-2 virus using COVID-19 Docking Server. It is observed that anisotine and vasicoline of Justicia adhatoda and Pemirolast are very good inhibitors. As all these three compounds are market available drugs, an immediate clinical trial is plausible which may lead to the golden success against the present pandemic. We prescribed different drugs for different purposes and stages of viral infection.

Keywords: COVID-19; Structure of SARS-CoV-2; Infection Mechanism of COVID-19; Model Drugs for COVID-19; Docking Study

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Citation

Citation: Abhrajit Bag and Arijit Bag. “Search for Natural Alkaloids as SARS-CoV-2 Proteas and RdRp Inhibitors: A Docking-Based Study". Acta Scientific Pharmaceutical Sciences 4.11 (2020): 77-81.




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Acceptance rate32%
Acceptance to publication20-30 days
Impact Factor0.759

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