Kwame G Yeboah1* and Aladin Siddig2
1College of Pharmacy, Harding University, Searcy, USA
2School of Pharmacy, University of Charleston, USA
*Corresponding Author: Kwame G Yeboah, College of Pharmacy, Harding University, Searcy, USA.
Received: September 22, 2018; Published: October 08, 2020
Purpose: Resveratrol has been reported to have beneficial effect against many diseases and has multi-spectrum therapeutic applications. However, oral delivery in its free form has short biological half-life with the consequent reduced bioavailability of only one percent. As such, the search continues for a polymer matrix that will be ideal for the protection of the drug and other compounds associated with food system from the conditions encountered in the gastrointestinal tract and to increase therapeutic efficiency.
Purpose of the Study: The purpose of this project therefore, was to evaluate the novel strategy of using albumin and glycine copolymer system to prepare microspheres capable of protecting the Resveratrol and meeting the sustained release specifications for increased bioavailability.
Method: Microspheres containing Resveratrol were prepared using BSA, Glycine and a mixture of BSA/Glycine polymer matrices. The comparative physicochemical characteristics such as particle sizes, zeta potential, drug release, and residual concentration of glutaraldehyde after the crosslinking process for six formulations were evaluated.
Results: The study showed that all the physicochemical characteristics of the selected BSA/Glycine microspheres were ideal for delivery of the resveratrol drug by the oral route. The drug substance was protected at extremely high temperature and oxygen stress. In addition, the residual glutaraldehyde concentrations were below the levels reported to be toxic for peroral delivery. Secondary, a novel means of neutralizing any excess glutaraldehyde by the use of sodium bisulfite was successful incorporated into the formulation.
Conclusion: It was concluded from the results of the study that BSA/Glycine copolymers can be used to produce microspheres with the required specifications for the oral delivery of bioactive compounds such as resveratrol.
Keywords: Resveratrol; Glutaraldehyde; Crosslinking; Glycine; Bioactive Compounds; Microspheres
Citation: Kwame G Yeboah and Aladin Siddig. “Formulation and Characterization of Albumin/Glycine Microspheres as Oral Delivery System for Resveratrol". Acta Scientific Pharmaceutical Sciences 4.11 (2020): 14-29.
Copyright: © 2020 Kwame G Yeboah and Aladin Siddig. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.