Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 6 Issue 7

Immune System Response to COVID-19. An Endless Story

Mohamed Raslan1, Eslam MS1, Sara AR1 and Nagwa A Sabri2*

1Drug Research Centre, Cairo, Egypt
2Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

*Corresponding Author: Nagwa A Sabri, Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Received: April 20, 2022; Published: June 16, 2022

Abstract

Background: Nowadays COVID-19 is the most widely spread viral infections all over the world. The relation between immune system response, coordination, existing comorbid conditions, viral proofreading, and severity of corona virus infection and increased mortalities requires some attention to be investigated and correlated.

Aim: Reviewing the immune system, types of immunity and investigating the effect of comorbidity and poly pharmacy on patients’ immunity system and response finally, the correlation between viral proofreading and severity of COVID-19 infection.

Discussion: Severity of COVID-19 infection can be attributed to immune dysregulation and loss of bridging between innate and adaptive immunity. Several factors and comorbid conditions contribute in such dysregulation, like age, obesity, pre-existing diseases, stress conditions. Besides, viral mutations that occurs as a result of proofreading mechanisms contributes in such diseases severity. Clinical pictures showed high white blood cell count, lower lymphocyte count, and high levels of reactive protein (CRP) in those patients died from COVID-19 compared to those recovered individuals. Several drug choices like hydroxychloroquine, Baricitinib, Beta-glucans proved to be effective in management and regulation of disrupted immune responses and improving clinical pictures. Conclusion: Immune dysregulation and other factors supporting such dysregulation showed to be the main leading cause for exacerbation of COVID-19 symptoms and increased mortalities. Different therapeutic choices showed to be effective in restoring immune coordination, and improving clinical signs and symptoms.

Keywords: COVID-19; Innate Immunity; Proofreading; Adaptive Immunity; Cytokines, Thymus-Derived Immunity

References

  1. Turvey SE and Broide DH. “Innate immunity”. The Journal of Allergy and Clinical Immunology2 (2010): S24-32.
  2. Bonilla FA and Oettgen HC. “Adaptive immunity”. The Journal of Allergy and Clinical Immunology2 (2010): S33-40.
  3. Aristizábal B and González Á. “Innate immune system”. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside Internet. Bogota (Colombia): El Rosario University Press; Chapter 2 (2013).
  4. Murphy KM., et al. “Janeway’s immunobiology”. 7. New York: Garland Science (2007).
  5. Frieman M., et al. “SARS coronavirus and innate immunity”. Virus Research 1 (2008): 101-112.
  6. Kawai T and Akira S. “Toll-like receptors and their crosstalk with other innate receptors in infection and immunity”. Immunity 5 (2011): 637-650.
  7. Marshall JS., et al. “An introduction to immunology and immunopathology”. Allergy, Asthma and Clinical Immunology 14 (2018): 49.
  8. Stone KD., et al. “IgE, mast cells, basophils, and eosinophils”. The Journal of Allergy and Clinical Immunology 125 (2010): S73-80.
  9. Mueller SN and Rouse BT. “Immune responses to viruses”. Clinical Immunology (2008): 421-431.
  10. Klimpel GR. “Immune Defenses”. In: Baron S, editor. Medical Microbiology. 4th Galveston (TX): University of Texas Medical Branch at Galveston; Chapter 50 (1996).
  11. von Andrian UH and Mempel TR. “Homing and cellular traffic in lymph nodes”. Nature Reviews on Immunology 3 (2003): 867-878.
  12. Deng Yan., et al. “Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study”. Chinese Medical Journal11 (2020): 1261-1267.
  13. Ma H., et al. “Visualizing the novel coronavirus (COVID-19) in children: What we learn from patients at Wuhan Children’s Hospital”. THE LANCET-D-20-0281 (Preprint research paper). Electronic copy.
  14. Vishal US Rao., et al. “COVID-19: Loss of bridging between innate and adaptive immunity?”. Medical Hypotheses 144 (2020): 109861.
  15. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  16. Xu Z., et al. “Pathological findings of COVID-19 associated with acute respiratory distress syndrome”. Lancet Respiratory Medicine 8 (2020): 420-422.
  17. Wu F., et al. “A new coronavirus associated with human respiratory disease in China”. Nature 579 (2020): 265-269.
  18. Catanzaro M., et al. “Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2”. Signal Transduction and Targeted Therapy 5 (2020): 84 (2020).
  19. Shi Y., et al. “Immunopathological characteristics of coronavirus disease 2019 cases in Guangzhou, China”. medRxiv (2020).
  20. Zhang B., et al. “Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19”. Frontiers in Molecular Biosciences (2020).
  21. Mehta P., et al. “COVID-19: consider cytokine storm syndromes and immunosuppression”. Lancet 395 (2020): 1033-1034.
  22. Perlman S and Dandekar A A. “Immunopathogenesis of coronavirus infections: implications for SARS”. Nature Reviews Immunology 5 (2005): 917-927.
  23. Tynell J., et al. “Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocytederived macrophages and dendritic cells”. Journal of General Virology 97 (2016): 344-355.
  24. Zhu N., et al. “A novel coronavirus from patients with pneumonia in China”. The New England Journal of Medicine 382 (2019): 727-733.
  25. Qin C., et al. “Dysregulation of immune response in patients with COVID-19 in Wuhan, China”. Infectious Diseases Society of America (2020).
  26. Chen D., et al. “Recurrence of positive SARS-CoV-2 RNA in COVID-19: a case report”. International Journal of Infectious Diseases 93 (2020): 297-299.
  27. Denison MR., et al. “Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity”. RNA Biology 8 (2011): 270-279.
  28. Smith EC., et al. “Implications of altered replication fidelity on the evolution and pathogenesis of coronaviruses”. Current Opinion in Virology 2 (2012): 519-524.
  29. Fran Robson., et al. “Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting”. Molecular Cell5 (2020): 710-727.
  30. Eckerle LD., et al. “High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants”. Journal of Virology 81 (2007): 12135-12144.
  31. Perlman S and Dandekar AA. “Immunopathogenesis of coronavirus infections: implications for SARS”. Nature Reviews Immunology12 (2005): 917-927.
  32. Song H D., et al. “Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human”. Proceedings of the National Academy of Sciences of the United States of America 102 (2005): 2430-2435.
  33. Zheng H-Y., et al. “Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients”. Cellular and Molecular Immunology 17 (2020): 541-543.
  34. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497-506.
  35. Wang W., et al. “High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients”. Cell Molecular 17 (2020): 650-652.
  36. Wilk AJ., et al. “A single-cell atlas of the peripheral immune response in patients with severe COVID-19”. Nature Medicine 26 (2020): 1070-1076.
  37. Chen T., et al. “Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study”. BMJ 368 (2020): m1295.
  38. Franceschi C and Campisi J. “Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases”. The Journals of Gerontology Series A Biological Sciences 69 (2014): S4-9.
  39. Callender LA., et al. “The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19”. Frontiers in Immunology 11 (2020): 1991.
  40. Li B., et al. “Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China”. Clinical Research on Cardiology 109 (2020): 531-538.
  41. Brian E Leonard. “The concept of depression as a dysfunction of the immune system”. Current Immunology Review 6 (2010): 205-212.
  42. , et al. “Depressive Disorders and Incidence of COVID-19: Is There a Correlation and Management Interference?” Psychological Disorders and Research 3.2 (2020): 2-7.
  43. Tufan A., et al. “COVID-19, immune system response, hyperinflammation and repurposing antirheumatic drugs”. Turkish Journal of Medical Sciences SI-1 (2020): 620-632.
  44. Vincenzo Bronte., et al. “Baricitinib restrains the immune dysregulation in COVID-19 patients”. June 30, 2020 (2020).
  45. Mirończuk-Chodakowska I., et al. “Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era”. Nutrients11 (2021): 3960.
  46. Ikewaki N., et al. “Immunological actions of Sophy beta-glucan (beta-1,3-1,6 glucan), currently available commercially as a health food supplement”. Microbiology and Immunology (2007).
  47. Kosagi-Sharaf., et al. “Role of Immune Dysregulation in Increased Mortality Among a Specific Subset of COVID-19 Patients and Immune-Enhancement Strategies for Combatting Through Nutritional Supplements”. Frontiers in Immunology 11 (2020): 1548.

Citation

Citation: Nagwa A Sabri., et al. “Immune System Response to COVID-19. An Endless Story". Acta Scientific Pharmaceutical Sciences 6.7 (2022): 24-31.

Copyright

Copyright: © 2022 Nagwa A Sabri., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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