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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 10

Drug Dose Adjustments in Chronic Kidney Disease Patients

Roja Rani K*, Prasanth Munaswamy and Susmitha Bhaskar Yerramasetty

Pharm D, Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tirupathi, Andhra Pradesh, India

*Corresponding Author: Roja Rani K, Pharm D, Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tirupathi, Andhra Pradesh, India.

Received: August 08, 2020; Published: September 28, 2020



  The incidence of Chronic Kidney Disease are extremely increasingly world wide due to rise in diabetes, hypertension, cardiovascular diseases. As kidney is a main eliminating organ, its function decreases in renal failure resulting in build up of drugs which cause toxic effects. The aim is to assess the prescribing drug dose adjustment in chronic kidney disease patients. Objectives are to predict glomerular filtration rate by using Modified diet in renal failure formulae. To assess the drug dose adjustments in renal failure patients. A prospective observational study was carried out in SVRRGGH during October 2016 to March 2017. A total of 125 patients diagnosed with CKD are included in study. Patients who are not willing, below 18 years, special population including pregnant, lactating women were excluded from study. Proforma was used to collect data. Total of 125 patients were included in study, men constituted 85(68%) of total population. Most effected age group was 51 - 60 years (29.60%). The study population with stage-4, 44 (35.20%) were higher. In total 1163 studied drugs, only 141 drugs are to be dose adjusted, out of that 94 (68.8%) were not dose adjusted and 47 (32.2%) were adjusted. It is concluded that more than half of drugs was not dose adjusted and there is need of dose adjustment in hospitalized chronic kidney disease patients. Continuous medical education of physicians and collaboration with clinical pharmacist is an important issue for quality improvement regarding renally impaired patients.

Keywords: Chronic Kidney Disease; Dose Adjustments; Renal Failure; Glomerular Filtration Rate



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Citation: Roja Rani K., et al. “Drug Dose Adjustments in Chronic Kidney Disease Patients". Acta Scientific Pharmaceutical Sciences 4.10 (2020): 143-151.


Acceptance rate32%
Acceptance to publication20-30 days

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