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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 10

Drug Dose Adjustments in Chronic Kidney Disease Patients

Roja Rani K*, Prasanth Munaswamy and Susmitha Bhaskar Yerramasetty

Pharm D, Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tirupathi, Andhra Pradesh, India

*Corresponding Author: Roja Rani K, Pharm D, Department of Pharmacy Practice, Sri Padmavathi School of Pharmacy, Tirupathi, Andhra Pradesh, India.

Received: August 08, 2020; Published: September 28, 2020

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Abstract

  The incidence of Chronic Kidney Disease are extremely increasingly world wide due to rise in diabetes, hypertension, cardiovascular diseases. As kidney is a main eliminating organ, its function decreases in renal failure resulting in build up of drugs which cause toxic effects. The aim is to assess the prescribing drug dose adjustment in chronic kidney disease patients. Objectives are to predict glomerular filtration rate by using Modified diet in renal failure formulae. To assess the drug dose adjustments in renal failure patients. A prospective observational study was carried out in SVRRGGH during October 2016 to March 2017. A total of 125 patients diagnosed with CKD are included in study. Patients who are not willing, below 18 years, special population including pregnant, lactating women were excluded from study. Proforma was used to collect data. Total of 125 patients were included in study, men constituted 85(68%) of total population. Most effected age group was 51 - 60 years (29.60%). The study population with stage-4, 44 (35.20%) were higher. In total 1163 studied drugs, only 141 drugs are to be dose adjusted, out of that 94 (68.8%) were not dose adjusted and 47 (32.2%) were adjusted. It is concluded that more than half of drugs was not dose adjusted and there is need of dose adjustment in hospitalized chronic kidney disease patients. Continuous medical education of physicians and collaboration with clinical pharmacist is an important issue for quality improvement regarding renally impaired patients.

Keywords: Chronic Kidney Disease; Dose Adjustments; Renal Failure; Glomerular Filtration Rate

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References

  1. National Kidney Foundation. “KDOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification”. American Journal of Kidney Diseases 39 (2002): S1-266.
  2. Sarah R Tomasello. “Chronic Kidney Disease”. Richard A. Helms,‎ David J. Quan, Eric T. Herfindal, Dick R.Gourley. Text book of therapeutics drug and disease management. 8th edition. United States of America: Lippincott Williams and Wilkins (2006): 1142-1175.
  3. Joanne M Bargman and Karl Skoreck. Chronic kidney disease. Anthony S.Fauci, Dennis L.Kasper,Dan L. Longo, Eugene Braunwald, Stephen L.Hauser, J. LarryJameson, Joseph Loscalzc. Harrisons Principles of internal medicine. 17th edition. New York: Mcgraw-hill (2008): 1762.
  4. Myrnay Munar and Harleen Singh. “Drug dosing adjustments in patients with chronic kidney disease”. American Family Physician 75 (2007): 1487-1496.
  5. Abdulrahman M Alahdal and Ahmed A. “Evaluation of applying drug dose adjustment by physicians in patients with renal impairment”. Saudi Pharmaceutical Journal 20 (2012): 217-220.
  6. Ahsan Saleem and Imran Masood. “Pattern and predictors of medication dosing errors in chronic kidney disease patients in Pakisthan: A single center retropective analysis”. Plos One (2016).
  7. Yahaya H., et al. “Drug use and dosing in chronic kidney disease”. Annals Academy of Medicine Singapore 12 (2009): 1095-1103.
  8. Kappel J and Calissi P. “Nephrology: Safe drug prescribing for patients with renal insufficiency”. Canadian Medical Association Journal 4 (2002): 473-477.
  9. Hudson JQ and Nyman HA. “Use of estimated glomerular rate rate for drug dosing in chronic kidney disease patient”. Current Opinion in Nephrology and Hypertension5 (2011): 482-491.
  10. Van Dijk Ea., et al. “Drug dosage adjustments according to renal function at hospital discharge”. Annals of Pharmacotherapy7 (2006): 1254-1260.
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Citation

Citation: Roja Rani K., et al. “Drug Dose Adjustments in Chronic Kidney Disease Patients". Acta Scientific Pharmaceutical Sciences 4.10 (2020): 143-151.




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Acceptance rate32%
Acceptance to publication20-30 days

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