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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 10

Evaluation of In-Vitro and In-Vivo Anticoagulant Activity of Orange Peel Extract

Tera Sandhya* and Pasumarthy Sree Mahalakshmi

Department of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupathi, India

*Corresponding Author: Tera Sandhya, Department of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Viswavidyalayam, Tirupathi, India.

Received: September 18, 2020; Published: September 21, 2020

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Abstract

  It is a common and necessary procedure that assist avert loss of life yet from slight damages by means of creating clumps or clots in an effort to discontinue bleeding from an injured or damaged vessel. The results acquired from this exploration advocate that the medicinal plant, Orange peel, possesses the capability to inhibit the aggregation of platelets: The extract of the plant peel inhibited the effect of thrombin on the artificial substrate (i.e. chromogenix), and subsequent too inhibited rat aggregation of platelets provoked with ADP, thrombin, and epinephrine. The anti-aggregation of Platelet effectiveness was seen mostly in the extract of the semi-polar solvent extract highest dose indicating the highest effect. The capability of the extract to inhibit the arachidonic acid provoked aggregation of Platelet signify its potential to be developed into an excellent pharmacological anti-platelet and anti-inflammatory medicament.

Keywords: Anticoagulant Activity; Orange Peel Extract; Platelet Aggregation

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References

  1. Nielson F., et al. “Plasma malondialdehyde as a biomarker for oxidative stress: Reference interval and effects of life-style factors”. Clinical Chemistry7 (1997): 1209-1214.
  2. Gadi D., et al. “Parsley extract inhibits in vitro and ex vivo platelet aggregation and prolongs bleeding time in rats”. Journal of Ethnopharmacology (2009): 125.
  3. Mekhfi M., et al. “An effect of extracts and tannins from Arbutus unedo leaves on rat platelet aggregation”. Phytotherapy Research 20 (2006): 135Œ139.
  4. Ambrosio G., et al. “Reactive oxygen metabolites and arterial thrombosis (Review)”. Cardiovascular Research 34 (1997): 445-452.
  5. Park BS Son., et al. “Antiplatelet effects of acid amides isolated from the fruits of Piper longum L”. Phytomedicine12 (2007): 853-855.
  6. M Cheesbrough. “Haematological tests: in District laboratory practice in tropical countries”. (London: Cambridge University Press (2000) 297.
  7. HL Reid and AC Ugwu. “A simple technique for rapid determination of plasma viscosity”. Nigerian Journal of Physiological Sciences 3 (1987): 45-48.
  8. GC Ingram GC. “A suggested schedule for rapid investigation of acute haemostatic failure”. Journal of Clinical Pathology 14 (1961): 156-160.
  9. DW Li., et al. “Long duration of anticoagulant activity and protective effects of acharan sulfate in vivo”. Thrombosis Research1 (2004): 67-73.
  10. Dutta-Roy AK., et al. “Effect of tomato extract on human platelet aggregation In vitro”. Platelets 4 (2001): 218Œ227.
  11. Tomita T., et al. “Basic aggregation properties of washed rat platelets: Correlation between aggregation, phospholipid degradation malondialdehyde, and thromboxane formation”. Journal of Pharmacology Methods1 (1983): 31-44.
  12. Kosela S., et al. “Effects of diterpene acids on malondialdehyde generation during thrombin induced aggregation of rat platelets”. Archives of Pharmacal Research5 (1986): 189-191.
  13. Vellini M., et al. “Possible involvement of eicosanoids in the pharmacological action of bromelain”. Arzneimittelforrschung1 (1986): 110-112.
  14. El Haouari., et al. “Inhibition of rat platelet aggregation by Urtica dioica leaves extracts”. Phytotherapy Research 20 (2006): 568-572.
  15. Chang ZQ., et al. “The in vitro antiplatelet, antioxidant and cellular immunity activity of Phellinus gilvus fractional extracts”. World Journal of Microbiology and Biotechnology2 (2008): 181-187.
  16. Parise LV., et al. “Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2 receptor interaction”. Journal of Pharmacology and Experimental Therapeutics1 (1984): 240-244.
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Citation

Citation: Tera Sandhya and Pasumarthy Sree Mahalakshmi. “Evaluation of In-Vitro and In-Vivo Anticoagulant Activity of Orange Peel Extract". Acta Scientific Pharmaceutical Sciences 4.10 (2020): 56-66.




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