J Josephine Leno Jenita1*, Mahesh AR2, Wilson B1 and Reddy Prasad3
1Department of Pharmaceutics, College of Pharmaceutical Sciences, School of Health
Sciences, Dayananda Sagar University, Bangalore, India
2Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences School of Health Sciences, Dayananda Sagar University, Bangalore, India
3Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Bangalore, India
*Corresponding Author: J Josephine Leno Jenita, Assistant Professor, Department of Pharmaceutics, College of Pharmaceutical Sciences, School of Health Sciences, Dayananda Sagar University, Bangalore, India.
Received: April 10, 2020; Published: September 18, 2020
Objective: The present study is to achieve colon-specific targeted delivery of oxaliplatin for the treatment of colon cancer and also to assess the use of Guar Gum, Locust Bean Gum, Chitosan alone and also with combination of Hydroxy propyl methyl cellulose (HPMC) in the form of a compression-coating on oxaliplatin core tablet.
Methods: The core tablet of 20 mg of Oxaliplatin was coated with various proportions of Guar Gum (GG), Locust Bean Gum (LBG), Chitosan (CS) and HPMC K-100 as a compression coating material. The effects of these polysaccharides, its level and the coat thickness were evaluated. All the batches were subjected for its potential in colon-specific drug delivery by conducting drug release studies in simulated gastric and intestinal fluids. The amount of oxaliplatin released from the compressed coated tablets at different time intervals was estimated by a UV Spectroscopy method.
Results: From the experimental studies the tablets coated with above mentioned coating materials alone with combination of polysaccharides have showed sustained drug release in the colonic environment. In vitro drug release studies was known to follow super case transport- II.
Conclusion: This study indicated that the use of polysaccharides that are biodegraded by colonic microflora could result in comparatively safer and more effective delivery of drugs to the colon and also a new means to achieve colon-specific drug delivery. This study also revealed that this approach prevents the oxaliplatin drug release in the upper gastrointestinal environment.
Keywords: Oxaliplatin; Guar Gum; Locust Bean Gum; Chitosan; Hydroxy Propyl Methyl Cellulose; Colon Specific Targeting
Citation: J Josephine Leno Jenita., et al. “Design and Evaluation of Oral Based Site Specific Targeting of Oxaliplatin to Colorectal Cancer".Acta Scientific Pharmaceutical Sciences 4.8 (2020): 22-30.
Copyright: © 2020 J Josephine Leno Jenita., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.