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Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Case Report Volume 4 Issue 8

Hepatic Rupture Complicating HELLP Syndrome and Pre-existent Antiphospholipid Syndrome with Cerebral Venous Sinus Thrombosis

Chinmayi Patkar-Kattimani1*, Riddhi Rathod1, Dinesh Sagtani2 and Prasad Kattimani1

1Specialty Doctor, Department of Anaesthesia and Intensive Care, Queen’s Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, Essex, United Kingdom
2Consultant, Department of Anaesthesia and Intensive Care, Queen’s Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, Essex, United Kingdom

*Corresponding Author: Chinmayi Patkar-Kattimani, Specialty Doctor, Department of Anaesthesia and Intensive Care, Queen’s Hospital, Barking, Havering and Redbridge University Hospitals NHS Trust, Romford, Essex, United Kingdom.

Received: June 08, 2020; Published: July 28, 2020

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Abstract

 Antiphospholipid syndrome is associated with HELLP (Haemolysis, Elevated Liver enzymes and Low Platelets) syndrome as a continuum of thrombotic microangiopathies. Subcapsular liver haematoma is a rare presentation of HELLP syndrome. A 38-year-old woman at 33 weeks gestation presented with HELLP syndrome complicated by acute hepatic rupture. She had background history of antiphospholipid syndrome with cerebral venous sinus thrombosis. Postoperative course was complicated by hepatic failure, sepsis and haemodynamic instability which was managed successfully. Anaesthetists need to be aware of serious complications like haemorrhage, thrombosis and multi-organ failure when presented with HELLP syndrome and antiphosholipid syndrome.

Keywords: HELLP Syndrome; Antiphospholipid Syndrome; Cerebral Venous Sinus Thrombosis; Subcapsular Liver Haematoma; Hepatic Rupture

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References

  1. Haram K., et al. “The HELLP syndrome: clinical issues and management. A Review”. BMC Pregnancy Childbirth1 (2009): 8.
  2. A Tufano., et al. “HELLP Syndrome and Its Relation with the Antiphospholipid Syndrome”. Vox Sanguinis1 (2014): 114-118.
  3. Luo Y., et al. “Diagnosis and Treatment of Cerebral Venous Thrombosis: A Review”. Frontier Aging Neuroscience 10 (2018): 2.
  4. Dag ZO., et al. “HELLP Syndrome and Cerebral Venous Sinus Thrombosis Associated with Factor V Leiden Mutation during Pregnancy”. Case Reports in Obstetrics and Gynecology (2014): 582890.
  5. Thuong D., et al. “The HELLP Syndrome in the Antiphospholipid Syndrome: Retrospective Study of 16 Cases in 15 Women”. Annals of the Rheumatic Diseases2 (2005): 273-278.
  6. Kazzaz NM., et al. “Treatment of catastrophic antiphospholipid syndrome”. Current Opinion on Rheumatology 3 (2016): 218-227.
  7. Aguiar CL and Erkan D. “Catastrophic antiphospholipid syndrome: how to diagnose a rare but highly fatal disease”. Therapeutic Advances in Musculoskeletal Disease 6 (2013): 305-314.
  8. Radu A., et al. “Pregnancy Management in Women with Antiphospholidic Syndrome”. Maedica (Buchar)2 (2019): 148-160.
  9. Kapan M., et al. “Subcapsular Liver Hematoma in HELLP Syndrome: Case Report”. Gastroenterology Research 3 (2010): 144-146.
  10. Troja A., et al. “Management of Spontaneous Hepatic Rupture on Top of HELLP Syndrome: Case Report and Review of the Literature”. Viszeralmedizin 3 (2015): 205-208.
  11. Mikolasevic I., et al. “Liver Disease During Pregnancy: A Challenging Clinical Issue”. Medical Science Monitor 24 (2018): 4080-4090.
  12. Haram K., et al. “The HELLP syndrome: clinical issues and management. A Review”. BMC Pregnancy Childbirth 9 (2009): 8.
  13. Wilson SG., et al. “The management of the surgical complications of HELLP syndrome”. Annals of the Royal College of Surgeons of England 7 (2014): 512-516.
  14. Shames BD., et al. “Liver transplantation for HELLP syndrome”. Liver Transplantation 11 (2005): 224-228.
  15. Jo YY., et al. “Anesthetic management of HELLP syndrome complicating primary antiphospholipid syndrome -A case report”. Korean Journal of Anesthesiology6 (2012): 575-578.
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Citation

Citation: Chinmayi Patkar-Kattimani., et al. “Hepatic Rupture Complicating HELLP Syndrome and Pre-existent Antiphospholipid Syndrome with Cerebral Venous Sinus Thrombosis". Acta Scientific Pharmaceutical Sciences 4.8 (2020): 112-115.




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