Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 8

Oenothera biennis L. Oil Extract Accelerated Wound Healing in Diabetic Mice Models: A Histomorphological Study

Seyed Ehsan Alavi1, Ramin Farhoudi2*, Mansoureh Ghezlou3 and Farzad Mokhtari4

1Department of Biology, Payame Noor University, Tehran, Iran
2Quality Control Department, Pasteur Institute of Iran, Tehran, Iran
3Biophysics Department, Science and Research Branch, Islamic Azad University, Tehran, Iran
4Bioorganic Lab, Biochemistry Department, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

*Corresponding Author: Ramin Farhoudi, Quality Control Department, Pasteur Institute of Iran, Tehran, Iran.

Received: June 06, 2020; Published: July 28, 2020



Wound care considered as a significant challenge in diabetic patients. Gradual progression of ulcer healing process in diabetes mellitus causes chronic wound infection and leads to amputation consequently. Neuropathy and angiopathy resulting from hyperglycemia are the main explanation of wound problems in these cases.

Phytochemical research showed that Oenothera biennis L (Evening Primrose) had a beneficial effect on inflammatory pathways and neuropathy in chronic disease such as diabetes. The most common mechanism of Evening Primrose (EP) extracts raised from its rich content of linolenic acids.

Here, we implemented an in vivo investigation to study the effect of EP oil on wound healing in alloxan-induced diabetic SW1 mice models. Results assessed by the degree of wound closure and histomophological scores analysis. The outcomes compare with zinc oxide as a conventional wound treatment remedy. Angiogenesis and population of essential cells in the tissue repair such as neutrophils, macrophages and fibroblasts in treated and control groups compare statistically.

The results showed accelerated new granulation tissue, wound closure and better histopathologic score throughout EP oil treatment than zinc oxide and control group after 7 and 14 days after wounding. We expect wound healing property of EP oil arising from modulating inflammation and alteration of cell membrane content according to its essential fatty acids specially Gamma-linolenic acid.

Keywords: Diabetic Wound Healing; Oenothera biennis L.; Evening Primrose Oil; Zinc Oxide



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Citation: Ramin Farhoudi., et al. “Oenothera biennis L. Oil Extract Accelerated Wound Healing in Diabetic Mice Models: A Histomorphological Study". Acta Scientific Pharmaceutical Sciences 4.8 (2020): 98-106.


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