Abstract

The hexamethyl tetraazamacrocyclic ligand salt, Me₆[14]diene. 2HClO₄(L.2HClO₄) has been synthesized by the condensation of ethylenediamine and acetone in the presence of HClO_4, then two isomeric ligands tet-a and tet-b have been isolated from its reduced form. These ligands produced bimetallic and monometallic nitratozinc(II) complexes with Zn(NO₃)₂.6H₂O. The nitratozinc(II) complexes, [(ZnL)₂(NO₃)](ClO₄)₃, [Zn(tet-a)(NO₃)₂] and [Zn(tet-b)(NO₃)₂] underwent axial addition and substitution reactions with KX (X= SCN, NO₂, I or Br) in proper ratio to produce twelve new corresponding monometallic six coordinated octahedral complexes. The newly prepared complexes have been characterized on the basis of elemental analyses, IR, UV-Vis, and ¹H-NMR spectroscopic, magnetic and molar conductivity data. Antibacterial activities of the ligands and complexes against different gram positive and gram negative bacteria have been investigated.

Keywords: Macrocyclic Ligands; Zinc(II) Complexes; Axial Addition and Substitution; Spectroscopic Studies; Antibacterial Activities

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Citation

Citation: Tapashi Ghosh Roy., et al. “Tetraazamacrocyclic Ligands and their Zinc(II) Complexes: Synthesis, Characterization and Biological Activities". Acta Scientific Pharmaceutical Sciences 4.8 (2020): 42-54.

Copyright

Copyright: © 2020 Tapashi Ghosh Roy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.