Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 4 Issue 7

Antioxidant Potential of Vernonia occephala

Usman M1*, Aliyu AB2, Momoh MA3 and Faruq UZ1

1Department of Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria
2Department of Chemistry, Ahmadu Bello University, Zaria, Nigeria
3Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria

*Corresponding Author: Usman M, Department of Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria.

Received: June 05, 2020; Published: June 30, 2020

×

Abstract

In this study, antioxidant activities of ethanolic extracts, ethyl acetate, n-butanol and chloroform fraction of Vernonia oocephala were evaluated using DPPH free radical scavenging assay, total phenolic contents, reducing power assay and total antioxidant capacity. The free radical scavenging activity expressed as percentage antioxidant activity was highest in ethyl acetate fraction of (EC50 = 20.0 ± 0.005 µg/ml). The total phenolic content was highest in ethyl acetate fraction (106.0 ± 0.003 mg/g GAE). Also, the ethyl acetate fraction exhibited the highest total antioxidant capacity (100 mg g-1 ascorbic acid equivalent). The chloroform fraction exhibited the highest reducing power at all concentrations. There is no significant difference between the standard and the sample (P ≤ 0.05). The results of this study have shown that Vernonia oocephala contains antioxidant chemical substances and therefore can be considered as a good source of natural antioxidants for medicinal uses.

Keywords: Vernonia amygdalina; Antioxidant Activity; DPPH; Folin-Ciocalteu

×

References

  1. Stuffness M and Douros J. “Current Status of the NCI Plant and animal Product Program”. Journal of Natural Products 45 (1982): 1-14.
  2. Baker JT., et al. “Natural product drug discovery and development: New perspective or international collaboration”. Journal of Natural Products 58 (1995): 1325-1357.
  3. Iwu MM. “Hand Book of African Medicinal Plants”. CRC Press, Inc. Florida (1993).
  4. Roja G and Rao PS. “Anticancer Compounds from Tissue Cultures of Medicinal plant”. Journal of Herbs, Spices and Medicinal Plants 7 (2000): 71-102.
  5. Katalinic V., et al. “Screening of 70 Medicinal Plant Extracts for Antioxidant Capacity and Total Phenols”. Food Chemistry 94 (2006): 550-557. 
  6. Mavi A., et al. “Antioxidant Properties of some Medicinal Plants: Prangos ferulacea (Apiaceae), Sedum semipervivoides (Crassulaceae), Malva neglecta (Malvaceae) Cruciata taurica (Rubiaceae), Rosa pimpinellifolia (Rosaceae), Galium verum Subsp. verum (Rubiaceae), Urica dioica (Urtricaceae)”. Biological and Pharmaceutical Bulletin 27 (2003): 702-705.
  7. Galato D., et al. “Antioxidant Capacity of Phenolic and Related compounds: Correlation among Electrochemical, Visible Spectroscopy Methods and Structure-Antioxidant Activity”. Redox Report 6 (2001): 243-250.
  8. Zhu X., et al. “Oxidative stress signaling in Alzheimer's disease”. Brain Research 1000 (2004): 32-39.
  9. Atoui AK., et al. “Tea and Herbal Infusions: Their Antioxidant Activity and Phenolic Profile”. Food Chemistry 89 (2005): 27-36.
  10. Middleton E and Kandaswami C. “The Impact of Plant Flavonoids on Mammalian Biology: Implications for Immunity, Inflammation and Cancer”. In The flavonoids: advances in research Since.; London, UK: Chapman and Hall (1994): 619-620. 
  11. Hou WC., et al. “Free Radical Scavenging Activity of Taiwanese Native Plants”. Phytomedicine 10 (2003): 170-175.
  12. Bilbis LS., et al. “Serum Level of Antioxidant Vitamins and Mineral Elements of HIV positive subjects in Sokoto, Nigeria”. Annals of African Medicine 9.4 (2010): 235-239.
  13. Aliyu AB., et al. “Antifeedant activity of Vernonia oocephala against stored product pest Tribolium casteneum (Herbst)”. Bangladesh Journal of Scientific and Industrial Research 49 (2015): 243-248.
  14. Aliyu AB., et al. “Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria”. Phytochemistry 111 (2015): 163-168.
  15. Cho EJ., et al. “Study on the Inhibitory Effects of Korean Medicinal Plants and their Main Compounds on the 1, 1-dipheny-2-picrylhydrazyl radical”. Phytomedicine 10 (2003): 544-551.
  16. Mensor LL., et al. “Screening of Brazilian Plant Extracts for Antioxidants Activity by the use of DPPH Free Radical Method”. Phytotherapy Research 15 (2001): 127-130.
  17. Mac Donald S., et al. “Phenolic Content and Antioxidant Activity of Olive Oil Extracts”. Food Chemistry 73 (2001): 73-84.
  18. Oyaizu M. “Studies on Products of Browning Reactions: Antioxidative Activities of Products of Browning reaction Prepared from Glucosamine”. The Japanese Journal of Nutrition 44 (1986): 307-315.
  19. Prieto P., et al. “Spectrophotometric Quantitation of Antioxidant Capacity through the Formation of a Phosphomolybdenum Complex: Specific application to the determination of vitamin E”. Analytical Biochemistry 269 (1999): 337-341.
  20. Ara N and Nur H. “In vitro Antioxidant activity of Methanolic leaves and flowers extracts of Lippia alba”. Research Journal of Medical Sciences 4.1 (2009): 107-110.
  21. Szabo MR., et al. “Improved DPPH determination for antioxidant activity spectrophotometric assay”. Chemical Papers 61.3 (2007): 214-216.
  22. Cotelle N., et al. “Antioxidant properties of hydroxyl flavones”. Free Radical Biology and Medicine 21 (1996): 35-43.
  23. Burda S and Oleszek W. “Antioxidant and Antiradical Activities of Flavonoids”. Journal of Agricultural and Food Chemistry 49 (2001): 2774-2779. 
×

Citation

Citation: Usman M., et al. “Antioxidant Potential of Vernonia occephala". Acta Scientific Pharmaceutical Sciences 4.7 (2020): 55-60.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is November 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US