Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 7

Formulation and Evalution of Telmisartan Solid Dispersion of Encapsulation Using Different Polymer

Kabita Banik* and K Yashasree

Department of Pharmaceutics, Bharat Institute of Technology (BIT), Mangalpally, Hyderabad, Telangana, India

*Corresponding Author: Kabita Banik, Department of Pharmaceutics, Bharat Institute of Technology (BIT), Mangalpally, Hyderabad, Telangana, India.

Received: January 17, 2020; Published: June 30, 2020

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Abstract

The aim of the present study was to improve the solubility and dissolution rate of a poorly water soluble drug, telmisartan by solid dispersion technique. The objective of the study is to prepare telmisartan solid dispersion and encapsulation using different polymers to achieve the enhanced solubility and to determine the Kinetic Modeling of Drug Release and Stability studies. Telmisartan has PH dependent solubility. Due to this reason only the % release for the prepared solid dispersions was higher in PH 4.5 acetate buffer when compared with other mediums. Based on mathematical data revealed from models, it was concluded that the release data was best fitted with First order kinetics. Stability studies showed that there were no significant changes in physical and chemical properties of capsule of formulation after 3 months.

Keywords: Solid dispersion; Telmisartan; PEG6000; PEG20000; HPMC E15; HPC LH21; β-Cyclodextrin

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References

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Citation

Citation: Kabita Banik and K Yashasree. “Formulation and Evalution of Telmisartan Solid Dispersion of Encapsulation Using Different Polymer". Acta Scientific Pharmaceutical Sciences 4.7 (2020): 41-48.




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Acceptance rate32%
Acceptance to publication20-30 days
Impact Factor0.759

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