Abstract

Some novel derivatives of 1,3-thiazine have been synthesized by the condensation of 2-hydroxy-3-nitro5-chlorochalcones with thiourea and phenylthiourea in ethanol containing aqueous KOH solution. The synthesized ten 1,3 thiazine derivatives were subjected to molecular docking studies against E.coli Glucosamine-6 P Synthase in Complex with Fructose-6 P (PDB ID-4 AMV) and Crystal structure of Peptide deformylase from Staphylococcus aureus Complex with Actinonin (PDB ID-1Q1Y) usingMolegro Virtual Docker software. All synthesized compound have been screened for in-vitro evaluation of antimicrobial activities by agar plate techniques. The results indicated that all the synthesized 1,3 thiazine derivatives shows considerable antimicrobial activities on gram negative (E. coli) bacteria This study suggested that 1,3-thiazine derivatives possess more antimicrobial activities on gram negative (E. coli) bacteria than gram positive bacteria (S.aureus).

Keywords: 1, 3 Thiazine; Molecular Docking; Antimicrobial Activities; Thiourea; Phenyl Thiourea

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Citation

Citation: Khan Sana., et al. “Molecular Docking Studies; 1,3 Thiazines Derivatives".Acta Scientific Pharmaceutical Sciences 4.7 (2020): 12-15.

Copyright

Copyright: © 2020 Khan Sana., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.