Abstract

  Prucalopride succinate is used for the treatment of chronic constipation. Four new UV spectrophotometric methods have been developed for the determination of Prucalopride succinate in pharmaceutical formulations. Prucalopride succinate is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation and thus normalizing bowel movements. Prucalopride succinate has shown absorption maxima (λmax) at 226 nm in reagents phosphate buffer (pH 2.0), 0.1N HCl and Beer-Lambert’s law was obeyed over the concentration range 5 - 60 μg/ml. Prucalopride succinate has also shown λmax at 222.60 nm and 228 nm in 0.1N NaOH and acetate buffer (pH 5.0) respectively and Beer-Lambert’s law was obeyed over the concentration range 5 - 50 μg/ml. All the four methods were validated as per ICH guidelines and the methods were found to be simple, precise and accurate and can be applied successfully for the assay of Prucalopride succinate for the pharmaceutical formulations.

Keywords:Prucalopride Succinate; Spectroscopy; Phosphate Buffer; Acetate Buffer; Sodium Hydroxide; HCl; Validation

References

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Citation

Citation: Goutham Dev Ashish Bojja and Mukthinuthalapati Mathrusri Annapurna. “Development and Validation of New Analytical Methods for the Quantification of Prucalopride Succinate". Acta Scientific Pharmaceutical Sciences 4.5 (2020): 74-77.