Abstract

  New derivative spectrophotometric methods have been developed for the assay of Ketorolac tromethamine in pharmaceutical formulations. Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug which exhibits pronounced analgesic and moderate anti-inflammatory activity. Ketorolac tromethamine was able to produce a first order derivative spectra in reagents such as phosphate buffers (pH 5.0 and 8.0), acetate buffer (pH 4.7), 0.1N NaOH and borate buffer (pH 9.0). In all these reagents the first order derivative spectra show both maxima and minima and therefore amplitude was chosen for constructing the calibration curves. Beer- Lambert’s law was obeyed over the concentration range 5 - 30 μg/ml for all the methods and the methods were validated as per ICH guidelines. The methods were found to be simple, precise, accurate, economical and the methods can be successfully applied for the determination of Ketorolac tromethamine in pharmaceutical dosage forms.

Keywords:Ketorolac Tromethamine; First Order Derivative Sspectroscopy; Sodium Hydroxide; Borate Buffer; Acetate Buffer; Phosphate Buffer; Validation; ICH Guidelines

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Citation

Citation: Mukthinuthalapati Mathrusri Annapurna.,et al. “First Derivative Spectrophotometric Methods for the Determination of Ketorolac Tromethamine Tablets". Acta Scientific Pharmaceutical Sciences 4.5 (2020): 70-73.