Duggirala Sree Harsha, Gunuputi Sushma and Mukthinuthalapati Mathrusri Annapurna*
GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, India
*Corresponding Author: Mukthinuthalapati Mathrusri Annapurna, GITAM Institute of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, India.
Received: April 13, 2020; Published: May 04, 2019
Five new spectrophotometric methods have been established for the determination of Ketorolac tromethamine in pharmaceutical formulations. Ketorolac tromethamine is Non-steroidal anti-inflammatory drug used to treat pain. Ketorolac tromethamine is chemically known as k benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. Ketorolac has shown absorption maxima at 323 nm in all the methods. Reagents used such as phosphate buffers (pH 5.0 and 8.0), acetate buffer (pH 4.7), 0.1N NaOH and borate buffer (pH 9.0). Ketorolac tromethamine obeys Beer-Lambert’s law over the concentration range 5 - 30 μg/ml for all the above mentioned methods and all the methods were validated as per ICH guidelines.
Keywords:Ketorolac Tromethamine; Spectroscopy; Phosphate Buffer; Borate Buffer; Acetate Buffer; Sodium Hydroxide, Validation
Citation: Mukthinuthalapati Mathrusri Annapurna., et al. “Development and Validation of New Analytical Methods for the Determination of Ketorolac
Tromethamine (A Non-Steroidal Anti-Inflammatory Agent)". Acta Scientific Pharmaceutical Sciences 4.5 (2020): 59-62.
Copyright: © 2020 Mukthinuthalapati Mathrusri Annapurna., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Copyright