Abstract

  In this study, Metal (II) Complexes of Mn (II), Fe (III), Co (II) and Ni (II) with Schiff base ligand derived from Trimethoprim and Cyclohexanone were synthesized and characterized using various physic-chemical techniques such as: solubility, conductivity, melting point determination, UV/Vis and Fourier transform infrared, 1H-NMR and elemental analysis. On the basis of these characterizations, a six coordinated octahedral geometry has been proposed for all the complexes. The Schiff base ligand and its complexes were screened for their antimicrobial activity against some pathogenic microbial isolate and compared with the parent drug. The antimicrobial activity results showed the following trend: metal complexes > Schiff base ligands > Parent drugs. This suggests potential antimicrobials agents with broad spectrum activity. Computational studies further revealed that M-Cl bond is responsible for the trend in antimicrobial properties among the complexes.

Keywords:Bacterial Resistance; Bacteria; Trimethoprim; Schiff Base; Complexes

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Citation

Citation: Hussaini Garba., et al. “Transition Metal Complexes of Schiff Base Ligand Derived from Trimethoprim with Cyclohexanone: Synthesis, Characterization, Antimicrobial and Computational Studies".Acta Scientific Pharmaceutical Sciences 4.5 (2020): 36-45.