Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 5

Transition Metal Complexes of Schiff Base Ligand Derived from Trimethoprim with Cyclohexanone: Synthesis, Characterization, Antimicrobial and Computational Studies

Hussaini Garba1*, Jamila Bashir Yakasai2, Ibrahim Waziri3 and Ibraheem O Bisiriyu4

1Department of Science Laboratory Technology, Ramat Polytechnic, Maiduguri, Borno State, Nigeria
2National Water Resources Institute, Mando, Kaduna State, Nigeria
3Department of Pure and Applied Chemistry, University of Maiduguri, Maiduguri, Nigeria
4Department of Chemical Sciences, Faculty of Science, University of Johannesburg, South Africa

*Corresponding Author: Hussaini Garba, Department of Science Laboratory Technology, Ramat Polytechnic, Maiduguri, Borno State, Nigeria.

Received: March 31, 2020; Published: April 29, 2019



  In this study, Metal (II) Complexes of Mn (II), Fe (III), Co (II) and Ni (II) with Schiff base ligand derived from Trimethoprim and Cyclohexanone were synthesized and characterized using various physic-chemical techniques such as: solubility, conductivity, melting point determination, UV/Vis and Fourier transform infrared, 1H-NMR and elemental analysis. On the basis of these characterizations, a six coordinated octahedral geometry has been proposed for all the complexes. The Schiff base ligand and its complexes were screened for their antimicrobial activity against some pathogenic microbial isolate and compared with the parent drug. The antimicrobial activity results showed the following trend: metal complexes > Schiff base ligands > Parent drugs. This suggests potential antimicrobials agents with broad spectrum activity. Computational studies further revealed that M-Cl bond is responsible for the trend in antimicrobial properties among the complexes.

Keywords:Bacterial Resistance; Bacteria; Trimethoprim; Schiff Base; Complexes



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Citation: Hussaini Garba., et al. “Transition Metal Complexes of Schiff Base Ligand Derived from Trimethoprim with Cyclohexanone: Synthesis, Characterization, Antimicrobial and Computational Studies".Acta Scientific Pharmaceutical Sciences 4.5 (2020): 36-45.


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