Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 5

ntimicrobial Activity of Ciprofloxacin-Loaded Softisan-154 Lipid Microparticles: Physicochemical Evaluation and In Vitro Activity

Momoh A Mumuni1*, Nafiu Aminu2, Frankline C Kenechukwu1, Agboke A Ayodeji3, Adedokun M Oluseun3, Oyeniyi Y James2, Parom K Stephen4, Obajuluwa A Funke4, Usman Muhammad4, Darlington Youngson1, Tochimen K Michel5, Omeje C Ernest6 and Emmanuel C Ibezim3

1Drug Delivery Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu State, Nigeria
2Department of Pharmaceutics and Pharm. Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
3Department of Pharmaceutics and Pharm. Microbiology, Faculty of Pharmacy, University of Uyo, Akwa-Ibom State, Nigeria
4Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences Kaduna State University, Kaduna, Nigeria
5Department of Chemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria
6Department of Pharmacognosy and Environmental Medicine Faculty of Pharmaceutical Sciences University of Nigeria Nsukka, Enugu State, Nigeria

*Corresponding Author: Momoh A Mumuni, Drug Delivery Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria Nsukka, Enugu State, Nigeria.

Received: February 10, 2019; Published: April 29, 2019

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Abstract

  The objective of this work was to prepare and investigate in vitro ciprofloxacin (CPX)-loaded solid lipid microparticles (SLM) against some selected micro-organisms for improved activity. Lipid matrix consisting of Softisan®-154 and Phospholipon® 90H was used to prepare SLMs loaded with CPX. The thermal properties of polymers and the SLMs were determined by a differential scanning calorimetry (DSC), particles size and the pH change of CPX-loaded SLMs were evaluated. The encapsulation efficiency (EE), loading capacity (LC) and in vitro release of CPX from the SLMs were evaluated. The antimicrobial activities of the SLM against selected organisms were determined. Characterizations showed that lipid matrix generated imperfect microstructure that accommodated CPX in a concentration-dependent manner. The EE and LC% were 89.2 and 33%, respectively. Maximum CPX release of > 80% was obtained in batch A3. The antimicrobial activity of the formulation against the tested organisms was comparably higher in batch C (49.10 ± 2.10) against S. aureus and (33.10 ± 0.21 mm) against S. typhii as compared to the reference sample. This result suggests the capability of the SLMs to modify the release of the drug and improve its activities against the microorganisms.

Keywords:Antimicrobial Activity; Ciprofloxacin; Hybrid; Lipid-Matrix

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Citation

Citation: Momoh A Mumuni., et al. “Antimicrobial Activity of Ciprofloxacin-Loaded Softisan-154 Lipid Microparticles: Physicochemical Evaluation and In Vitro Activity". Acta Scientific Pharmaceutical Sciences 4.5 (2020): 30-35.



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