Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 4 Issue 3

Isolation of One Compound from Ageratum conyzoides L. Leaves Responsible for UV Radiation Absorption

Tanaya Ghosh1, Prasenjit Mitra2 and Prasanta Kumar Mitra1*

1Department of Medical Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
2Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India

*Corresponding Author: Prasanta Kumar Mitra, Professor and Head, Department of Medical Biotechnology, Sikkim Manipal University, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.

Received: January 20, 2020; Published: February 24, 2020



  Solar UV radiation is one of the important environmental risk factors for development of non-melanoma skin cancer. It can also cause atrophy, wrinkling, pigmentary changes, photosensitivity reactions to ingested drugs etc. Efforts are, therefore, going on to invent sources through which solar UV rays can be absorbed. Recently we have shown that ethanol extract of Ageratum conyzoides Linn (A. conyzoides L.) leaves of summer sample has maximum UV radiation absorption activity. Aim of the present work was to isolate the active compound(s) from the A. conyzoides L. leaves responsible for UV radiation absorption. A. conyzoides L. leaves were collected in summer, identified by the taxonomist and processed for isolation work to get the active compound responsible for UV radiation absorption property by standard methods. Solvent extraction and acid hydrolysis were done followed by solvent treatment, chromatographic experiments. Finally a compound was crystallized. UV absorption property of the isolated compound was studied. The compound showed maximum absorption at 200 nm. The compound, therefore, may be used to prepare sun screen lotion to protect humans from UV radiation.

Keywords: Ageratum conyzoides Linn. Leaves; UV Absorbing Property; Isolation of Active Compound; Sun Screen Lotion.



  1. MacKie RM. “Effects of Ultraviolet Radiation on Human Health”. Radiation Protection Dosimetry 91.1 (2000): 15-18. 
  2. D’Orazio., et al. “UV Radiation and the Skin”. International Journal of Molecular Sciences 14 (2013): 12222-12248.
  3. Elwood JM and Jopson J. “Melanoma and sun exposure: An overview of published studies”. International Journal of Cancer 73 (1997): 198-203.
  4. Gupta Vandana., et al. “Environment friendly antibacterial and uv protective finish on cotton using S. cumini (l.) leaves extract”. International Journal of Textile and Fashion Technology 7.1 (2017): 53-62.
  5. Napagoda MT., et al. “Photoprotective potential in some medicinal plants used to treat skin diseases in Sri Lanka”. BMC Complementary and Alternative Medicine 16 (2016): 479-502.
  6. Cannell RJP. “Natural Products Isolation”. New Jersey Human Press Inc. (1998): 165-208.
  7. Li HB., et al. “Separation methods used for Scutellaria baicalensis active components”. Journal of Chromatography 8.12 (2004): 277-290.
  8. Huie CW. “A review of modern sample-preparation techniques for the extraction and analysis of medicinal plants”. Analytical and Bioanalytical Chemistry 373 (2002): 23-30.
  9. Sasidharan S., et al. “Extraction, Isolation and Characterization of Bioactive Compounds from Plants' Extracts”. African Journal of Traditional, Complementary and Alternative Medicines 8.1 (2011): 1-10. 
  10. Bambal Vaishali., et al. “Study of sunscreen activity of herbal cream containing flower extract of Nyctanthes arbortristis L. and Tagetes erecta L”. International Journal of Pharmaceutical Sciences Review and Research 11.1 (2011): 142-146.
  11. Macari., et al. “Antioxidant, cytotoxic and UVB-absorbing activity of Maytenus guyanensis Klotzch. (Celastraceae) bark extracts”. Acta Amazonica 36.4 (2006): 513-518.
  12. Gajanan GV and Adhikrao Y. “Study of Methanolic Extract of Leaves Calotropis gigantea (L.) As an Anti-Solar”. Advances in Complementary and Alternative Medicine 1 (2018): 1-3.
  13. Patil., et al. “Study of methanolic extract of flower of Spathodea campanulata L. as an anti-solar”. International Journal of Green Pharmacy 3.3 (2009): 248-249.
  14. Mitra., et al. “Anti Solar Activity of Costus speciosus Leaves of Sikkim Himalayas”. Scholars Academic Journal of Pharmacy 9.1 (2020): 5-8. 
  15. Mitra., et al. “Isolation of Anti Solar Compound from Costus Speciosus Leaves”. Scholars Academic Journal of Pharmacy 9.1 (2020): 18-22. 
  16. Kaur R and Dogra NK. “A Review on Traditional Uses, Chemical Constituents and Pharmacology of Ageratum conyzoides L. (Asteraceae)”. International Journal of Pharmaceutical and Biological Archives 5.5 (2014): 33-45.


Citation: Prasanta Kumar Mitra., et al. “Isolation of One Compound from Ageratum conyzoides L. Leaves Responsible for UV Radiation Absorption" Acta Scientific Pharmaceutical Sciences 4.2 (2020): 02-05.

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