Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 4 Issue 2

Review on Analytical Profile of Venlafaxine HCl

Rajveer S Bhaskar1*, Monika B Ola2, Amod S Patil3 and Kamlesh R Chaudhari1

1Department of Quality Assurance, RCPIPER, Shirpur, India
2Department of Pharmaceutics, RCPIPER, Shirpur, India
3Department of Pharmaceutical Chemistry, RCPIPER, Shirpur, India

*Corresponding Author: Rajveer S Bhaskar, Department of Quality Assurance, RCPIPER, Shirpur, India.

Received: January 21, 2020; Published: January 27, 2020

Reprints View PDF Related Articles

×

Abstract

  Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may be unbalanced in people with depression. It is used to treat major depressive disorder, anxiety and panic disorder. The present review assesses the various approaches for analysis of Venlafaxine in bulk drug as well as various formulations. A concise review represents the compilation and discussion of about more than 35 analytical methods which includes HPLC, HPTLC, UPLC, LC-MS and UV-Spectrophotometry methods implemented for investigation of Venlafaxine in biological matrices, bulk samples and in different dosage formulations. This detailed review will be of great help to the researcher who is working on Venlafaxine.

Keywords: Venlafaxine; Analytical Profile; HPLC; HPTLC; Bioanalytical; Stability Indicating

×

References

  1. Khalifa Majed., et al. “Mechanism of sodium channel block by venlafaxine in guinea pig ventricular myocytes”. Journal of Pharmacology and Experimental Therapeutics 291.1 (1999): 280-284.
  2. Rao B Koteswara., et al. "Validation of stability indicating RP-HPLC method for the assay of venlafaxine in pharmaceutical dosage form”. Pharmacia Letter 7 (2015): 247-256.
  3. Somasekha Vanita., et al. “Development and validation of a rapid RP-HPLC method for the determination of venlafaxine hydrochloride in pharmaceutical dosage forms using experimental design”. Journal of Chemistry 6.4 (2009): 1091-1102.
  4. Nageswara Rao R and A Narasa Raju. "Simultaneous separation and determination of process‐related substances and degradation products of venlafaxine by reversed‐phase HPLC". Journal of Separation Science 29.18 (2006): 2733-2744.
  5. Siddiqui Masoom Raza., et al. “Analytical techniques in pharmaceutical analysis: A review”. Arabian Journal of chemistry 10 (2017): S1409-S1421.
  6. Samanidou Victoria., et al. “A simple HPLC method for the simultaneous determination of venlafaxine and its major metabolite O-desmethylvenlafaxine in human serum”. Bioanalysis 3.15 (2011): 1713-1718.
  7. Asafu-Adjaye Ebenezer B., et al. "Validation and application of a stability-indicating HPLC method for the in vitro determination of gastric and intestinal stability of venlafaxine”. Journal of Pharmaceutical and Biomedical Analysis 43.5 (2007): 1854-1859.
  8. Rao B., et al. “Validation of Venlafaxine in Pharmaceutical Dosage by Reverse Phase HPLC”. Journal of Pharmacy Research 5.5 (2012): 2683-2687.
  9. Peikova Lily., et al. “Development of HPLC method for determination of Venlafaxine during concomitant use of metoprolol”. Pharmacia 60 (2013): 12-16.
  10. Younus Mohammad., et al. "Determination of venlafaxine and modafinil in individual tablet dosage forms using single RP-HPLC method”. Tropical Journal of Pharmaceutical Research 12.2 (2013): 239-245.
  11. Liu Wen., et al. "Development and validation of a HPLC‐MS/MS method for the determination of venlafaxine enantiomers and application to a pharmacokinetic study in healthy Chinese volunteers”. Biomedical Chromatography 25.3 (2011): 412-416.
  12. Samnani B and KS Kumar. "Development and validation of a new HPLC method for simultaneous determination of esomeprazole, venlafaxine HCl and fenofibrate”. (2014).
  13. Nageswara Rao R and A Narasa Raju. "Simultaneous separation and determination of process‐related substances and degradation products of venlafaxine by reversed‐phase HPLC”. Journal of Separation Science 29.18 (2006): 2733-2744.
  14. Panchumarthy., et al. “Development and validation of isocratic RP-HPLC method for determination of venlafaxine bulk and tablet dosage form” (2009).
  15. Malik Aamir., et al. "Determination of Iron Chelating Agents by Analytical Methods: A Review”. Critical Reviews in Analytical Chemistry (2019): 1-11.
  16. Guideline, ICH Harmonised Tripartite. "Text on validation of analytical procedures”. International Conference on Harmonization, Geneva (1994).
  17. Karani Nikhil A and Prashant Pingale. "Analytical method development and validation of venlafaxine hydrochloride in solid dosage forms using UV spectrophotometer”. Journal of Pharma Research 2 (2009): 1246-1249.
  18. Pakhale Bhagyashree A., et al. “Development and Validation of Spectrophotometric Method for Determination of Venlafaxine Hydrochloride” (2015).
  19. Eswarudu MM., et al. “New simple UV-spectrophotometric method for determination of venlafaxine hydrochloride in pure and pharmaceutical formulation” (2017).
  20. Sowmya C., et al. "Development and validation of spectrophotometric method for the estimation of venlafaxine in bulk and formulations”. International Journal of Chemical Sciences 9.1 (2011): 52-58.
  21. Rathore Garvendra Singh., et al. "Spectrophotometric estimation of Venlafaxine hydrochloride”. Asian Journal of Chemistry 21.8 (2009): 5908.
  22. Raghubabu K., et al. "Simple and inexpensive methods development for determination of venlafaxine hydrochloride from its solid dosage forms by visible spectrophotometry”. Journal of Chemistry 9.3 (2012): 1645-1654.
  23. Hosseini Maryam. "Application of UV-spectrophotometry and HPLC for determination of venlafaxine and its four related substances in pharmaceutical dosage forms”. Turkish Journal Of Pharmaceutical Sciences 8.2 (2011): 91-104.
  24. Hala A. "HPTLC instrumentation: an overview”. Pharmatutor Pharmacy Infopedia (2015).
  25. Redasani VK., et al. “Development and Validation of Venlafaxine Hydrochloride in Bulk and in Capsule Formulation by HPTLC”. Journal of Analytical and Pharmaceutical Research 4.2 (2017): 00103.
  26. Jain Ankita., et al. "High Performance Thin Layer Chromatography (HPTLC): A Modern Analytical Tool for Chemical Analysis”. Current Research in Pharmaceutical Sciences (2014): 8-14.
  27. Phoujdar., et al. “Development and validation of HPTLC method for determination of venlafaxine HCl in API and pharmaceutical dosage form”. (2015).
  28. Shirvi Vimal., et al. "HPTLC analysis of venlafaxine hydrochloride in the bulk drug and tablets”. JPC-Journal of Planar Chromatography-Modern TLC 23.5 (2010): 369-372.
  29. Bakshi Monika and Saranjit Singh. "Development of validated stability-indicating assay methods—critical review”. Journal of Pharmaceutical and Biomedical Analysis 28.6 (2002): 1011-1040.
  30. Dolan John W. "Stability-indicating assays”. LC GC North America 20.4 (2002): 346-349.
  31. Smela JW. "Regulatory considerations for stability indicating analytical methods in drug substance and drug product testing”. American Pharmaceutical Review 8.3 (2005): 51-54.
  32. Blessy MRDP., et al. "Development of forced degradation and stability indicating studies of drugs—A review”. Journal of Pharmaceutical Analysis 4.3 (2014): 159-165.
  33. Guideline, ICH Harmonised Tripartite. "Stability testing of new drug substances and products”. Q1A (R2), current step 4 (2003): 1-24.
  34. Guideline, ICH Harmonised Tripartite. "Stability testing: photostability testing of new drug substances and products”. Q1B, Current Step 4 (1996).
  35. Guideline, ICH Harmonised Tripartite. "Validation of analytical procedures: text and methodology Q2 (R1)”. International conference on harmonization, Geneva, Switzerland (2005).
  36. Kaur Jaspreet., et al. "Development and validation of stability indicating method for the quantitative determination of venlafaxine hydrochloride in extended release formulation using high performance liquid chromatography”. Journal of Pharmacy and Bioallied Sciences 2.1 (2010): 22.
  37. Srinivas., et al. “Stability indicating method of related impurities in venlafaxine hydrochloride sustained release tablets" (2014).
  38. Rao Karri Visweswara., et al. “Stability indicating LC method for rapid determination of related substances of O-desmethyl venlafaxine in active pharmaceutical ingredients and pharmaceutical formulations”. Journal of Chromatographic Science 52.10 (2014): 1247-1254.
  39. Makhija Sapna N and Pradeep R Vavia. "Stability indicating LC method for the estimation of venlafaxine in pharmaceutical formulations”. Journal of Pharmaceutical and Biomedical Analysis 28.6 (2002): 1055-1059.
  40. Bernardi Larissa S., et al. "Development and validation of a stability-indicating method for the determination of venlafaxine in extended-release capsules and dissolution kinetic studies”. Journal of Chromatographic Science 47.9 (2009): 770-776.
  41. Dubey Sunil K., et al. “Stability indicating high performance thin layer chromatographic method for quantitation of venlafaxine in bulk and pharmaceutical dosage form”. Drug Development and Therapeutics 6.1 (2015): 33.
  42. Ramesh Bokka., et al. "Stability-indicating HPTLC method for analysis of venlafaxine hydrochloride, and use of the method to study degradation kinetics”. JPC-Journal of Planar Chromatography-Modern TLC 24.2 (2011): 160-165.
  43. Tiwari Gaurav and Ruchi Tiwari. "Bioanalytical method validation: An updated review”. Pharmaceutical Methods 1.1 (2010): 25-38.
  44. Shah Vinod P., et al. "Bioanalytical method validation—a revisit with a decade of progress”. Pharmaceutical Research 17.12 (2000): 1551-1557.
  45. Matoga M., et al. "Rapid high-performance liquid chromatographic measurement of venlafaxine and O-desmethylvenlafaxine in human plasma: application to management of acute intoxications”. Journal of Chromatography B: Biomedical Sciences and Applications 760.2 (2001): 213-218.
  46. Phoujdar Mannish., et al. “Development and validation of HPTLC method for determination of venlafaxine HCl in API and pharmaceutical dosage form”. (2015).
  47. Liu Wen and Feng Wang. "Simultaneous stereoselective analysis of venlafaxine and O-desmethylvenlafaxine enantiomers in human plasma by HPLC-ESI/MS using a vancomycin chiral column”. Journal of Chromatography B 850.1-2 (2007): 183-189.
  48. Liu Wen and Hua-lin Cai. "High performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI) method for simultaneous determination of venlafaxine and its three metabolites in human plasma”. Journal of Chromatography B 850.1-2 (2007): 405-411.
  49. Qin Feng., et al. "Simultaneous quantification of venlafaxine and O-desmethylvenlafaxine in human plasma by ultra-performance liquid chromatography–tandem mass spectrometry and its application in a pharmacokinetic study”. Journal of Chromatography B 878.7-8 (2010): 689-694.
  50. Shah Gaurang R., et al. "Simultaneous determination of venlafaxine and its main active metabolite O-desmethyl venlafaxine in rat plasma by LC-MS/MS”. Analytical Sciences 25.10 (2009): 1207-1210.
  51. Dziurkowska Ewelina and Marek Wesolowski. "Simultaneous quantitation of venlafaxine and its main metabolite, O‐desmethylvenlafaxine, in human saliva by HPLC”. Journal of Separation Science 36.11 (2013): 1726-1733.
  52. Dubey Sunil Kumar., et al. "Rapid sensitive validated UPLC–MS method for determination of venlafaxine and its metabolite in rat plasma: Application to pharmacokinetic study”. Journal of Pharmaceutical Analysis 3.6 (2013): 466-471.
×

Citation

Citation: Rajveer S Bhaskar., et al. “Review on Analytical Profile of Venlafaxine HCl". Acta Scientific Pharmaceutical Sciences 4.2 (2020): 85-88.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 30, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US





Creative Commons License Open Access by Acta Scientific is licensed under a Creative Commons Attribution 4.0 International License
Based on a work at https://actascientific.com

ff

Acta-Publications

ff

© 2021 Acta Scientific, All rights reserved.