Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 8

Phytochemical Screening and GC-MS Analysis of Methanol Extract of the Leaves of Nerium oleander Linn

Debashisa Mishra1*, Susanta Kumar Rout2 and Alaka Priyadarshani Kar1

1IMT Pharmacy College, Odisha, India
2Patent Information Centre, Science and Technology Department, Secretariat, Odisha, India

*Corresponding Author: Debashisa Mishra, IMT Pharmacy College, Odisha, India.

Received: June 08, 2018; Published: July 04, 2018

Citation: Debashisa Mishra., et al. “Phytochemical Screening and GC-MS Analysis of Methanol Extract of the Leaves of Nerium oleander Linn”. Acta Scientific Pharmaceutical Sciences 2.8 (2018).


   Nerium oleander Linn is one of the medicinally important plants belonging to the family Apocynaceae has been studied for different activities with special reference to Central Nervous System (CNS) disorder along with wound healing, anti-oxidant effect. The experimental results showed that N. oleander Linn has effective in various disorders. The plant’s methanol extract at 300 mg/kg showed highly significant result towards different animal models mimicking the different CNS disorder. Similarly the sub maximal dose i.e. 150 mg/kg showed significant effect in few animal models. The wound healing and antioxidant study showed also showed significant effect in different tests. Different literature study revealed that the plant extract has antibacterial activity, antifungal activity, antibiotic activity anticancer property. Since the plant’s producing different activities. GC-MS analysis in the leaf powder’s methanol extract was done by using National Institute Standard and Technology (NIST) database 2005 to identify the compounds present. The spectra of unknown compounds were compared with that of known compounds stored in the NIST library by matching the molecular weight and retention time. Sixteen numbers of phytochemical constituents those are bioactive in nature were identified in N. oleander Linn methanol leaf extract. The compounds predominantly Phenolic compounds, Flavonoids derivatives, Carbohydrate, Glycoside, Saponin, Phytosterols on basis of the molecular formula, molecular weight, peak area percentage etc. The phytochemicals present in the methanol extract might have produced different biological activities which have already been studied. It may suggest that, the phyto constituents may help to give protection from different kind of diseases.

Keywords: Phytochemicals; GCMS Analysis; Spectra; Antibacterial Activity

Copyright: © 2018 Debashisa Mishra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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