Acta Scientific Pharmaceutical Sciences

Review ArticleVolume 2 Issue 7

Antimicrobial Resistance in Patients with Acute Exacerbation of COPD

Salma Messous1,2*, Mohamed Habib Grissa1, Malek Mzali1, Imen Gannoun1, Imen Trabelsi1, Maha Mastouri2 and Semir Nouira1

1Research Laboratory (LR12SP18), University of Monastir, Tunisia
2Microbiology Laboratory, Fattouma Bourguiba University Hospital Monastir, Tunisia

*Corresponding Author: Salma Messous, University of Monastir, Microbiology Laboratory, Fattouma Bourguiba University Hospital Monastir, Tunisia.

Received: March 19, 2018; Published: June 08, 2018

Citation: Salma Messous Salma Messous., et al. “Antimicrobial Resistance in Patients with Acute Exacerbation of COPD”. Acta Scientific Pharmaceutical Sciences 2.7 (2018).

Abstract

Objective:To assess the prevalence of bacterial infection of patients admitted to the emergency room for an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and studied the antimicrobial resistance.

Methods: It was a descriptive and analytical study including patients hospitalized for AECOPD. Bacteriological examination included a cytobacteriological sputum exam and serological tests.

Results: Of the 240 patients enrolled, 175 sputum cultures (73%) were considered significant. Twenty-nine cultures were positive (16.5%) and 31 microorganisms were isolated which the most frequent were P. aeruginosa (25.8%), K. pneumoniae (16.2%), H. influenzae (13%) and S. pneumoniae (9.7%). The prevalence of C. pneumoniae, M. pneumoniae and C. burnetii was respectively 8.4%, 9% and 6.6%. No L. pneumophila infection was found. The positive culture are associated with Anthonisen criteria (p = 0.004). Almost half (40.9%) of the isolates were resistant to conventional first line antibiotics [43.7% Amoxicillin-Clavulanic acid].

Conclusion: The low positivity of quantitative sputum bacteriology and the large percentage of resistant strains with a predominance of exclusively multiresistant Pseudomonas can help in the management of patients with AECOPD.

Keywords: AECOPD; Bacterial Infection; Atypical Microorganism; Bacterial Resistance

Copyright: © 2018 Salma Messous., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In



News and Events


  • Submission Timeline for Regular Issue
    Last date for submission of articles for regular Issues is October 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US