Acta Scientific Pharmaceutical Sciences

Review ArticleVolume 2 Issue 7

Antimicrobial Resistance in Patients with Acute Exacerbation of COPD

Salma Messous1,2*, Mohamed Habib Grissa1, Malek Mzali1, Imen Gannoun1, Imen Trabelsi1, Maha Mastouri2 and Semir Nouira1

1Research Laboratory (LR12SP18), University of Monastir, Tunisia
2Microbiology Laboratory, Fattouma Bourguiba University Hospital Monastir, Tunisia

*Corresponding Author: Salma Messous, University of Monastir, Microbiology Laboratory, Fattouma Bourguiba University Hospital Monastir, Tunisia.

Received: March 19, 2018; Published: June 08, 2018

Citation: Salma Messous Salma Messous., et al. “Antimicrobial Resistance in Patients with Acute Exacerbation of COPD”. Acta Scientific Pharmaceutical Sciences 2.7 (2018).


Objective:To assess the prevalence of bacterial infection of patients admitted to the emergency room for an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and studied the antimicrobial resistance.

Methods: It was a descriptive and analytical study including patients hospitalized for AECOPD. Bacteriological examination included a cytobacteriological sputum exam and serological tests.

Results: Of the 240 patients enrolled, 175 sputum cultures (73%) were considered significant. Twenty-nine cultures were positive (16.5%) and 31 microorganisms were isolated which the most frequent were P. aeruginosa (25.8%), K. pneumoniae (16.2%), H. influenzae (13%) and S. pneumoniae (9.7%). The prevalence of C. pneumoniae, M. pneumoniae and C. burnetii was respectively 8.4%, 9% and 6.6%. No L. pneumophila infection was found. The positive culture are associated with Anthonisen criteria (p = 0.004). Almost half (40.9%) of the isolates were resistant to conventional first line antibiotics [43.7% Amoxicillin-Clavulanic acid].

Conclusion: The low positivity of quantitative sputum bacteriology and the large percentage of resistant strains with a predominance of exclusively multiresistant Pseudomonas can help in the management of patients with AECOPD.

Keywords: AECOPD; Bacterial Infection; Atypical Microorganism; Bacterial Resistance

Copyright: © 2018 Salma Messous., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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