Acta Scientific Pharmaceutical Sciences

Review ArticleVolume 2 Issue 7

Calcium, Vitamin-D and Hypertension: Interaction, Risk and Benefit

Seriki A Samuel1* and Odetola O Anthony2

1Department of Human Physiology, College of Medicine, Bingham University, Nigeria
2Department of Human Physiology, College of Health Sciences, Nnamdi Azikwe University, Awka, Nigeria

*Corresponding Author: Seriki A Samuel, Department of Human Physiology, College of Medicine. Bingham University, Nigeria.

Received: March 06, 2018; Published: June 08, 2018

Citation: Seriki A Samuel and Odetola O Anthony. “Calcium, Vitamin-D and Hypertension: Interaction, Risk and Benefit”. Acta Scientific Pharmaceutical Sciences 2.7 (2018).


  Hypertension is an anomaly when the blood pressure exerted by the blood on the blood vessels is higher than normal. Severe complications associated with hypertension include heart diseases, stroke and death. Blood pressure is generally the force exerted by the blood against the walls of the blood vessels. The pressure depends on the work being done by the heart and the resistance of the blood vessels. When a patient has a blood pressure higher than 130/80 mmHg, such patient is considered hypertensive according to guidelines issued by the American Heart Association (AHA) in November 2017. The current review is to examine the interaction between hypertension and Calcium and Vitamin D. It’s been observed that Calcium and Vitamin D may separately and collectively protect the cardiovascular system (CVS) and reduce risks of developing hypertension. While calcium binds to fatty acids and bile acids in the gut, resulting in malabsorption of fat, and a direct effect on adipocytes with increased lipolysis, vitamin D binds with vitamin-D receptors on the cells produced by many cells in the muscle that lines the blood vessels cells preventing free flow of blood in the vessels. Their beneficial effects alone are however not sufficient to make them sole antihypertensive drugs in the treatment/management of hypertension.

Keywords: Hypertension; High Blood Pressure; Vitamin D; Calcium; Calcification; Vascular Events

Copyright: © 2018 Seriki A Samuel and Odetola O Anthony. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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