Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 7

Studies on Inorganic Materials Based Antiulcer Pharmaceutical Gel for Oral Cavity: Formulation and Evaluation

Sabir Shaikh1* and Amol Shete2

1Department of Formulation and Development, S Kant Health Care R&D Centre, Navi Mumbai, Maharashtra, India
2Department of pharmaceutics, Krishna Institute of Pharmacy of Krishna Institute Medical Sciences Deemed University, Karad, Maharashtra, India

*Corresponding Author: Sabir Shaikh, Department of Formulation and Development, S Kant Health Care R&D Centre, Navi Mumbai, Maharashtra, India.

Received: February 13, 2018; Published: June 07, 2018

Citation: Sabir Shaikh and Amol Shete. “Studies on Inorganic Materials Based Antiulcer Pharmaceutical Gel for Oral Cavity: Formulation and Evaluation”. Acta Scientific Pharmaceutical Sciences 2.7 (2018).

Abstract

  The objective of the present investigations was to formulate and evaluate inorganic gel for mouth ulcer treatment containing inorganic materials like Tankan bhasma and Gairik bhasma.

  The present investigations were based on the objective of formulating and evaluating an inorganic gel for mouth ulcer treatment using Tankan bhasma and Gairik bhasma. This inorganic gel was prepared by using different concentrations of Tankan bhasma and Gairik bhasma and Carpobol 394, Propylene glycol as a gel base.

  Formulations were evaluated for various parameters like pre-compression parameters, infrared spectroscopy, and post-compression parameters invitro antifungal study, invitro dissolution study, and also evaluation of the stability batch.

  By infrared analysis it was revealed that there was no interaction between drugs and polymer. Excellent efficacy against Aspergillus aureus, Candida albicans was shown by the anti-fungal studies done for this formulation. This gel prepared was transparent, homogenous and the pH ranges from 7 to 7.5. This formulation showed the properties of applicable spreadability and excludability with the acceptable rheological behavior. Percent drug content of the inorganic gel formulations were found to be in the range of 90 ± 0.52% to 93 ± 0.55%. Optimized inorganic gel formulation shows good drug release of 40.83 ± 0.50, 39.216 ± 0.47 and 71.405 ± 0.07 at the end of 4 hours. The result of stability study indicated that formulation was stable at room temperature.

Developed formulation was stable, safe and effective for treatment of mouth ulcer.

Keywords: Tankan Bhasma; Gairik Bhasma; Gel

Copyright: © 2018 Sabir Shaikh and Amol Shete. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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