Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 6

Quantitative Estimation of Carfilzomib by UV-AUC Method

Pritam S Jain*, Swati D Yeole, Najeef A Ansari and Sanjay J Surana

R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, India

*Corresponding Author: Pritam S Jain, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, India.

Received: April 06, 2018; Published: May 29, 2018

Citation: Pritam S Jain., et al. “Quantitative Estimation of Carfilzomib by UV-AUC Method”. Acta Scientific Pharmaceutical Sciences 2.6 (2018).


Aim: The aim of this work is to establish a novel, simple, precise and sensitive UV-AUC spectrophotometric method has been developed for estimation of Carfilzomib from bulk and in-house formulation. Moreover, this work is performed to validate as per ICH guidelines.

Materials and Methods: Carfilzomib working standard was obtained as gift sample from Cipla Pharmaceuticals, Mumbai. In Methods, a stock standard solution was prepared by dissolving 100 mg of Carfilzomib in 100 mL of ethanol to obtain a concentration of 1000 μg/mL. After suitable dilution, 100 μg/mL of Carfilzomib prepared and scanned in the UV-visible range 400 - 200 nm; Carfilzomib showed a maximum wavelength at 258 nm. The Method applied was area under curve (AUC in which area under curve was integrated in the wavelength range of 256.80 - 261.20.

Results: The drug follows linearity in the concentration range 100 - 600 μg/mL with correlation coefficient value 0.999. The developed method was implemented to the marketed formulation and the evaluated % amount of drug was found in good consistency with the label claim.

Conclusion: The proposed method was a rapid, economical and commercial quality-control tool for routine analysis of Carfilzomib in bulk and in pharmaceutical formulations.

Keywords: Carfilzomib; UV Method; Validation; Quantitative Determination

Copyright: © 2018 Pritam S Jain., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate32%
Acceptance to publication20-30 days

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US