Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 6

PAntifungal Gel of Miconazole Nitrate: A Comparative Effect Study with Accumulation of Antioxidants and Surfactants

Shailesh Sharma1, Varunjot Kaur2, Kanika Mahajan2, Simran Pal Singh3 Pragi Arora2 Varun Arora2 Geeta Yadav2*

1ASBASJSM College of Pharmacy, Bela, Ropar, India
2Department of Pharmacy, Manav Bharti University, Himachal Pradesh, India
3Reckitt Benckiser Healthcare India Private Limited, Baddi, Himachal Pradesh, India

*Corresponding Author: Geeta Yadav, Department of Pharmacy, Manav Bharti University, Solan, Himachal Pradesh, India.

Received: March 26, 2018; Published: May 21, 2018

Citation: Geeta Yadav., et al. “Antifungal Gel of Miconazole Nitrate: A Comparative Effect Study with Accumulation of Antioxidants and Surfactants”. Acta Scientific Pharmaceutical Sciences 2.6 (2018).

Abstract

  OMiconazole nitrate is widely used as an antifungal drug with a poor aqueous solubility, which requires the development of new delivery systems to improve its therapeutic activity. Fungal infections are caused by the microscopic organisms that invade the epithelial tissue. However, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are known as potent antioxidants with antimicrobial properties. In an attempt to develop a better formulation with an antifungal profile, a surfactant aided micellar system was dispersed within miconazole nitrate gel formulation. In the proposed study, the prepared gel was evaluated for its physiochemical properties, in vitro drug release profile. It can be concluded that the addition of antioxidants and surfactants gives more promised effect in the release of miconazole nitrate.

Keywords: Antioxidants; Micellar System; Miconazole Nitrate; Topical Gel; Antifungal Activity

Copyright: © 2018 Geeta Yadav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In



News and Events


  • Special Issue on Reviews
    Acta Scientific Journals has been started Special Issue on Reviews, researchers from world wide welcoming for submission of their reviews on any topic by on/ before August 30, 2019. Special Issue is going to be released on September 10, 2019
  • Submission Timeline for Regular Issue
    Last date for submission of articles is August 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US