Shailesh Sharma¹, Varunjot Kaur², Kanika Mahajan², Simran Pal Singh³ Pragi Arora²Varun Arora²Geeta Yadav²*

¹ASBASJSM College of Pharmacy, Bela, Ropar, India
²Department of Pharmacy, Manav Bharti University, Himachal Pradesh, India
³Reckitt Benckiser Healthcare India Private Limited, Baddi, Himachal Pradesh, India

*Corresponding Author: Geeta Yadav, Department of Pharmacy, Manav Bharti University, Solan, Himachal Pradesh, India.

Received: March 26, 2018; Published: May 21, 2018

Citation: Geeta Yadav., et al. “Antifungal Gel of Miconazole Nitrate: A Comparative Effect Study with Accumulation of Antioxidants and Surfactants”. Acta Scientific Pharmaceutical Sciences 2.6 (2018).

Abstract

  OMiconazole nitrate is widely used as an antifungal drug with a poor aqueous solubility, which requires the development of new delivery systems to improve its therapeutic activity. Fungal infections are caused by the microscopic organisms that invade the epithelial tissue. However, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are known as potent antioxidants with antimicrobial properties. In an attempt to develop a better formulation with an antifungal profile, a surfactant aided micellar system was dispersed within miconazole nitrate gel formulation. In the proposed study, the prepared gel was evaluated for its physiochemical properties, in vitro drug release profile. It can be concluded that the addition of antioxidants and surfactants gives more promised effect in the release of miconazole nitrate.

Keywords: Antioxidants; Micellar System; Miconazole Nitrate; Topical Gel; Antifungal Activity

Copyright: © 2018 Geeta Yadav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.