Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 6

Solubility Enhancement of Etodolac Chewable Tablet Using Honey, and Evaluation with (Doe) Design of Experiment

Sameer Shakur Sheaikh1*, Rahul P Gaikwad1, Amir A Shaikh2, Yogesh D Pawar2 and Bhushan D Gavit2

1Durgamata Institute of Pharmacy, Dharmapuri, Maharashtra, India
2Indira College of Pharmacy, Tathwade, Pune, India

*Corresponding Author: Sameer Shakur Sheaikh, Durgamata Institute of Pharmacy, Dharmapuri, Maharashtra, India.

Received: April 16, 2018; Published: May 15, 2018

Citation: Sameer Shakur Sheaikh., et al. “DSolubility Enhancement of Etodolac Chewable Tablet Using Honey, and Evaluation with (Doe) Design of Experiment”. Acta Scientific Pharmaceutical Sciences 2.6 (2018).

Abstract

Objective: Drug authentication, improve solubility of drug, Preparation and Evaluation of solid dispersion, Use of honey in formulation development, Preparation of chewable tablet and Stability study

Method: Drug and polymers in different ratios (1:1, 1:2 and 1:4) were prepared to study the effect of individual polymer on solubility of Etodolac. High pressure homogenizer and solvent evaporation method was used to investigate the combined effect of PVP K30 and BCD on saturation solubility, percent cumulative drug release (% CDR) of Etodolac. Design of experiment (DoE) was used for preparation and evaluation of solid dispersion. Drug polymer interaction were analyzed with Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) with all combination of solid dispersion, and selection of honey as an antiulcer (GI). Design of experiment (DoE) was used for preparation and evaluation of chewable tablet.

Result: Different combination of PVP K30 and BCD prepared using design of expert (DoE) approach by high pressure homogenizer and solvent evaporation method showed greater solubility of Etodolac than its physical mixtures. Result of FTIR, DSC and XRD revealed the interaction between Etodolac PVP K30 and BCD. Increase percent cumulative drug release (% CDR) of solid dispersion (SD). This suggested formation and evaluation of ETO chewable tablet. Increasing in percent cumulative drug release (% CDR) of Etodolac chewable tablet.

Conclusion: Design of experiment (DoE) was predicted combination of PVP K30 and BCD, it was a more effective combination for preparation of Etodolac chewable tablet.

Keywords: Etodolac; High Pressure Homogenizer; Solvent Evaporation; Polyvinyl Pyrrolidone K30; Hydroxypropyl Β-Cyclodextrin; Design of Experiments; Chewable Tablet

Copyright: © 2018 Sameer Shakur Sheaikh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Member In



News and Events


  • Submission Timeline for Regular Issue
    Last date for submission of articles for regular Issues is October 30, 2019.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US