Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 5

Transforming Murrayanine-Chalcone into Corresponding 3H-Benzo[b] [1,4] Diazepine Derivatives: Accessing the Anti-Anxiety Effect by Inhibition of Locomotor Activity

Debarshi Kar Mahapatra1*, Ruchi S Shivhare2 and Kanhaiya M Dadure3

1Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India
2Department of Pharmaceutical Chemistry, Kamla Nehru College of Pharmacy, Nagpur, Maharashtra, India
3Department of Chemistry, J. B. College of Science, Wardha, Maharashtra, India

*Corresponding Author: Debarshi Kar Mahapatra, Assistant Professor, Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India.

Received: March 21, 2018; Published: April 25, 2018

Citation: Debarshi Kar Mahapatra., et al. “Transforming Murrayanine-Chalcone into Corresponding 3H-Benzo[b] [1,4] Diazepine Derivatives: Accessing the Anti-Anxiety Effect by Inhibition of Locomotor Activity”. Acta Scientific Pharmaceutical Sciences 2.5 (2018).

Abstract

  The numerous positive results and broad avenues of research on Murrayanine, a heterocyclic compound (carbazole) obtained from Indian curry plant Murraya koenigii L. (Rutaceae) have attracted us in developing semi-synthetic products with better pharmacodynamics and pharmacokinetic profiles. From our research group, various therapeutically active murrayanine based hybrid compounds have been developed where the extracted murrayanine was cyclized to various five/six-membered heterocyclic components such as isoxazole, thiazole, phthalimide, pyrazole, pyrimidine, hydantoin, Schiff ’s bases, etc. which demonstrated multifarious pharmacological activities like anti-oxidant, anti-convulsant, anti-bacterial, anti-fungal, anti-cancer, anti-diabetic, and anti-inflammatory. The present research aimed at developing several seven-membered heterocycle 3H-benzo[b][1,4]diazepine derivatives from Murrayanine-Chalcone, a hybrid compound previously reported by our research group by cyclization reaction and exploring the anti-anxiety or hypnotic effects of the fabricated molecule by evaluating locomotor inhibitory activity in Swiss albino rat. The study revealed the perspective to fabricate semi-synthetic heterocycles from murrayanine, which is a natural product and thus render desired safety and efficacy. The sophisticated analytical and spectroscopic tools revealed that the compounds were found to be in close agreement with that of the proposed structure. The influence of position, number, and the type of substituent were comprehensively studied where the lipophilic substituent containing scaffold (3h) presented the highest locomotor inhibition and therefore will translate antianxiety effect therapeutically. The study will open new avenues of research and will surely motivate the researchers in the rational development of safe and efficacious molecules in future from natural origin.

Keywords: Murrayanine; Chalcone; Benzodiazepine; Heterocycle; Locomotor; Murraya koenigii

Copyright: © 2018 Debarshi Kar Mahapatra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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