Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 5

Effect of Lead Poisoning and Antidepressant Drug on the Cerebral Cortex of the Wister Rats

SM Highab1*, RA Magaji2 and BY Muhammad3

1Department of Physiology and Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, Federal University Dutse, Jigawa State, Nigeria
2Department of Human Physiology, Faculty of Medical, Ahmadu Bello University, Zaria, Kaduna State, Nigeria
3Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah, Qassim, KSA

*Corresponding Author: SM Highab, Department of Physiology and Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, Federal University Dutse, Jigawa State, Nigeria.

Received: February 10, 2018; Published: April 11, 2018

Citation: Neelima Dhingra., et al. “Pyrazolic Chalcone Derivatives Targeting Cyclin Dependant Kinase: In-Silico Molecular Docking, ADME and Druglikeness Studies". Acta Scientific Pharmaceutical Sciences 2.5 (2018).


  The aim of this experiment is to investigate the effect of lead poisoning and antidepressant drug on the cerebral cortex of the wistar rats. The study employed thirty (30) wistar rats (150 - 200g) divided equally into five (5) groups: the first group (Negative control) was administered 1 ml/Kg of 0.9% saline once daily; second group depressed group (positive control) was administered 100 mg/kg of methyl isobutyl ketone once in one week; third group was administered 100 mg/kg of lead acetate (LA) once daily for one week; fourth group was administered 200 mg/kg of LA once daily for one week and fifth group was administered 200 mg/kg of LA once daily for one week and treated with 30 mg/kg of Imipramine once daily for one week. All treatments were administered intraperitoneally for one week while the fifth group was for two weeks. Behavioural test was carried out on the LA induced depression using Forced Swim Test (FST) and Open Field Test (OFT). The brain tissues were examined for histopathological parameters. The result indicated that there was significant (p < 0.05) increase in the duration of immobility in groups that received 100 mg/kg and 200 mg/kg of lead acetate when compared with the depressed control group. Activities of the rats in Open Field were also reduced. LA caused alterations and degeneration of the pyramidal and the cortical cells respectively and the effects was seen to have increased as LA dose increases. Therefore, it is concluded that histopathological observations in the 100 mg/kg and 200 mg/kg of LA of the brain showed degeneration of the cortical and pyramidal cells causing scattered shrunken neuronal cells with deeply stained cytoplasm, pyknotic nuclei, neuronal chromatolysis and the reduction in the staining ability of some neuronal cells.

Keywords: Lead Poisoning; Antidepressant Drug; Wistar Rat; Cerebral Cortex

Copyright: © 2018 SM Highab., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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