Acta Scientific Pharmaceutical Sciences

Research ArticleVolume 2 Issue 5

Synthesis, Characterization and Antihypertensive Activity of 4,5 Dihydropyridazin-3(2H)-One Derivatives

Vikas Jakhmola1,2, Sunil Jawla1 and Ravinesh Mishra3*

1Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India
2Department of Pharmacy, GRD (PG) IMT, Dehradun, Uttarakhand, India
3School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi (Solans), Himachal Pradesh, India

*Corresponding Author: Ravinesh Mishra, Associate Professor, School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Baddi (Solan), Himachal Pradesh, India.

Received: March 09, 2018; Published: April 03, 2018

Citation: Ravinesh Mishra., et al. “Synthesis, Characterization and Antihypertensive Activity of 4,5 Dihydropyridazin-3(2H)-One Derivatives”. Acta Scientific Pharmaceutical Sciences 2.5 (2018).

Abstract

  Some new 6-(substitutedphenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-phenyl substituted 2,3,4,5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (VJ1, VJ22) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity.

Keywords: β-Aroyl Propionic Acid; Pyridazinone; Antihypertensive Activity; Non-Invasive Method

Copyright: © 2018 Ravinesh Mishra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



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