H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan
*Corresponding Author: Iqra Munir, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi Pakistan.
Received: February 03, 2018; Published: March 21, 2018
Citation: Iqra Munir. “Protein Engineering; Structural Manipulations Leading to Desired Properties. A Mini Review”. Acta Scientific Pharmaceutical Sciences 2.4 (2018).
Proteins; the workhorses of the cells of living organisms, are produced from instructions encoded into cellular DNA. The protein identity is dictated by a unique sequence of twenty chemicals known as amino acids which first come together in various combinations to form longer chains of polypeptides. So, called because they are held together by covalent linkages-the peptide bonds, these polypeptides in turn assume a 3D structure augmented by various non-covalent associations such as hydrogen bonding, electrostatic interactions, hydrophobic forces and van der waals forces and often the covalent disulfide bonds. This allows proteins the liberty of being structural and functional building blocks in the cells, earning the reputation as “workhorses of the cells” and playing many roles in cellular physiology .
Keywords: Protein Engineering; Proteins
Copyright: © 2018 Iqra Munir. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.