A Supriya*, J Sundaraseelan, BR Srinivas Murthy and M Bindu Priya

Department of Pharmaceutics, Jawaharlal Nehru Technological University Anantapur, India

*Corresponding Author: A Supriya, Department of Pharmaceutics, Sri Padmavathi School of Pharmacy, Jawaharlal Nehru Technological University Anantapur, India.

Received: January 12, 2018; Published: February 07, 2018

Citation: A Supriya., et al. “Formulation and Evaluation of Capsules of Asenapine Maleate Loaded Chitosan Nanoparticles”. Acta Scientific Pharmaceutical Sciences 2.3 (2018).

Abstract

  Asenapine Maleate is an antipsychotic drug which has poor bioavailability due to its insolubility in water and belongs to biopharmaceutics Classification-IV. The aim of this study is to enhance the bioavailability of Asenapine Maleate by the preparation of Nanoparticles using ionic gelation method. In present work different formulations were prepared by using different ratios of polymer, Tween 80 (stabilizer) and sodium tri polyphosphate (cross linking agent). Prepared Nanoparticle was evaluated for its Particle Size, zeta potential, scanning electron microscopy, Percentage practical yield, Drug Entrapment Efficiency, and in-vitro drug release studies. NPs formulation was subsequently loaded into hard gelatin capsules that were evaluated for preformulation studies, in-vitro dissolution and pharmacokinetic behavior. The optimized CSNPs was found with particle size of 41.1 nm, zeta potential -9.9 Mv, percentage practical yield was 97.5%. Entrapment efficiency (%EE) of 65.7%, scanning electron microscopy irregular shape. The in-vitro release profile was found to be 92.5% sustained up to 510 minutes. Thus, incorporation of Asenapine maleate into CSNPs results in enhanced bioavailability when compared to pure drug.