Shahnaz Sultana^1,2, Mohammed Ali¹* and Showkat Rassol Mir¹

¹Phytochemistry Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delh, India
²College of Pharmacy, Jazan University, Jazan, Saudi Arabia

*Corresponding Author: Mohammed Ali, Phytochemistry Research Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Received: December 29, 2017; Published: February 05, 2018

Citation: Mohammed Ali., et al. “Chemical Constituents from the Aerial Parts of Jasminum auriculatum Vahl and Seeds of Holarrhena pubescens Wall. ex G. Don”. Acta Scientific Pharmaceutical Sciences 2.3 (2018).

Abstract

  Jasminum auriculatum Vahl (Oleaceae) is found in south eastern Asia as a small, evergreen and climbing shrub and used to treat bile problems, burning sensation, constipation, flatulence, kidney stones, leprosy, skin diseases, strangury, stomatitis, ulcers and wounds. Holarrhena pubescens Wall. ex G. Don (Apocynaceae) is distributed in the Indian subcontinent. Its seeds are effective to treat asthma, colic pain, chest infections, common cold and fever. Our study was planned to isolate chemical constituents from the aerial parts of J. auriculatum and seeds of H. pubescens and to characterize their structures. The air-dried plant materials were exhaustively extracted separately with methanol in a Soxhlet apparatus. The concentrated methanol extracts were adsorbed on silica gel (60 - 120 mesh) for the preparation of slurries. The dried slurries were chromatographed individually over silica gel columns. The columns were eluted with petroleum ether, chloroform and methanol, successively, in order of increasing polarity to isolate the chemical constituents.

  Phytochemical investigation of a methanol extract of the aerial parts of J. auriculatum afforded five new phytoconstituents identified as (Z)-n-dotriacont-6-enyl piperate [(Z)-n-dotriacontenyl piperate, 1], (Z)-4-pentadecanoxyferulic acid (2), (Z)-n-tri-acont-8-enoic acid [(Z)-8-dehydromelissic acid, 3], (Z)-dodec-6-enoyl - O-β-D-glucopyranosyl - 6′→1′′)-O-β-D-glucopyranosyl- (6′′→1′′′)-O-β-D-glucopyranosyl- (6′′′→1′′′′)-O-β-D-glucopyranoside [(Z)-6-lauroleiyl β-D-tetraglucoside, 5] and (Z )-dodec-6-eno-yl - O-α-D-glucopyranosyl -(6′→1′′)-O-α-D-glucopyranosyl-(6′′→1′′′)-O-α-D-glucopyranosyl- (6′′′→1′′′′)-O-α-D-glucopyranoside [(Z)-6-lauroleiyl α-D-tetraglucoside, 6] along with β-D-xylose (4). The seeds f H. pubescens gave a new aromatic ester (Z)-5′-(2-hydroxyphenyl)-pent-4-enyl ricinoleate (7). Their structures were established on the basis of spectral data analysis and chemical reactions.

Keywords: Jasminum auriculatum Aerial Parts; Holarrhena pubescens Seeds; Chemical Constituents; Isolation; Characterization

Copyright: © 2018 Mohammed Ali., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.