Roshan Pandit ^1,2, Harish Chandra Upreti ^1,3, Rekha Manandhar Shrestha ¹, Uday Kumar Yadav ^1,4, Rameshwar Das ^1,4 and Binod Kumar Yadav^2,5*

¹ National Public Health Laboratory, Department of Health Services, Ministry of Health and Population, Kathmandu, Nepal
²Madhesh Institute of Health Sciences, Janakpurdham, Madhesh Province, Nepal
³Devdaha Medical College and Research Institute Pvt. Ltd., Kathmandu University, Nepal
⁴Province Public Health Laboratory, Janakpurdham, Madhesh Province, Nepal
⁵Department of Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal

*Corresponding Author: Binod Kumar Yadav, Department of Biochemistry, Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Received: March 22, 2025; Published: April 04, 2025

Abstract

Introduction: Sickling disorder is an umbrella term comprising all pathologies that arise due to the presence of sickle hemoglobin (HbS). HbS has been reported to cause several changes to the red blood cells leading to the development of different clinical syn drome. This study aimed to assess the associated risks in school-going children with sickling disorder in a steady state.

Methods: A cross-sectional study was carried out at National Public Health Laboratory (NPHL) for six months (March – July 2019) and samples were collected from patients visiting NPHL for hemoglobinopathies diagnosis. A total of sixty case subjects and fifty, age and sex matched control subjects were included. Following laboratory investigation, the data was analyzed using a statistical pack age for social sciences (SPSS) software. ANOVA and Student’s t-test were used to compare between case and control subjects, and a p-value less than 0.05 at 95% confidence interval was considered statistically significant.

Results: School-aged sickling disorder patients showed a significant difference in the level of hemoglobin, PCV, MCV, MCHC, RDW CV, and platelets. The level of triglyceride (p-value 0.000) was significantly higher while the level of HDL cholesterol (p-value 0.012) was significantly lower in sickling disorder patients suggesting an increased risk for cardiovascular disease. Likewise, the level of total bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) were also significantly increased in sickling disorder patients indicating an increased risk for liver disease.

Conclusions: This study suggested an increased risk for liver and cardiovascular disease in school-aged children with sickling dis order in steady state.

Keywords: Sickle Cell; Hemoglobinopathies; Cardiovascular Risk; Liver Dysfunction; Nepal

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Citation

Citation: Binod Kumar Yadav.,et al. “Hematological and Biochemical Alterations in School-Aged Children with Sickling Disorders Indicate an Elevated Risk of Liver and Cardiovascular Diseases" Acta Scientific Paediatrics 8.3 (2025): 36-41.

Copyright

Copyright: © 2025 Binod Kumar Yadav.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.