Khwaja Amtul Raouf Qazi ¹*, Narmeen Jameel², Sumaiyya Jahan², Mohammed Maaz Aqeel² and Nihal Ahmed Khan²

¹Assistant Professor, Department of Pharmacy Practice, Sultan-ul-Uloom College of Pharmacy, Hyderabad- 500034, Telangana, India
²Department of Pharmacy Practice, Sultan-ul-Uloom College of Pharmacy, Hyderabad- 500034, Telangana, India

*Corresponding Author: Khwaja Amtul Raouf Qazi, Assistant Professor, Department of Pharmacy Practice, Sultan-ul-Uloom College of Pharmacy, Hyderabad- 500034, Telangana, India.

Received: February 27, 2025; Published: March 10, 2025

Abstract

Despite the success of radical prostatectomy in many cases, a subset of patients experiences biochemical or structural relapse so, postoperative radiation therapy i.e., Salvage radiotherapy in combination with Androgen deprivation therapy (ADT) is one such treatment option for managing patients with prostate cancer recurrence. The primary objective of our study was to assess the overall survival postprostatectomy relapse patients treated using salvage RT along with ADT. The secondary objective was to assess if com bining these therapies can enhance freedom from progression by maintaining PSA levels.

The sample size consists of 118 patients who were recruited over 6 years between October 2017 and December 2023. Survival probabilities were estimated using Kaplan-Meier and x2 test based on the radiation dose.

Results: The overall survival rate was 80.52% and it was found that factors such as age (x² = 5.801, p < 0.05), PSA (x² = 28.676, p < 0.05), regional lymph node involvement (x² = 0.473, p < 0.05), were statistically significant, suggesting that more than one predictor variables are related to survival.

Keywords: Structural Relapse; Salvage Radiotherapy; Radical Prostatectomy; Survival; Prognostic Factors

References

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Citation

Citation: Khwaja Amtul Raouf Qazi., et al. “Retrospective Study of Outcomes of Salvage RT with ADT in Patients of CA Prostate with Relapse". Acta Scientific Paediatrics 8.3 (2025): 15-23.

Copyright

Copyright: © 2025 Khwaja Amtul Raouf Qazi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.